ReviewHuman molecular genetics2010
Fine-scale population structure and the era of next-generation sequencing.
Review in Human molecular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Can Radiofrequency Ablation Replace Liver Resection for Solitary Colorectal Liver Metastasis? A Systemic Review and Meta-Analysis.Frontiers in oncology · 2020Pooled it
- Appreciating diversity: a review of the Iranian genomic landscape.European journal of human genetics : EJHG · 2026Review
- Fine-scale structure of a whole regional population through genetics and genealogies.Nature communications · 2026Article
- Lack of Population Structure of an Extreme Migratory Shorebird: Evidence of Gene Flow Between Geographically Disparate Populations.Ecology and evolution · 2026Article
- Genome-Wide Association Studies of Chemotherapeutic Toxicities: Genomics of Inequality.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Review
- Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk.Nature genetics · 2017Article
- Fine-scale human genetic structure in Western France.European journal of human genetics : EJHG · 2015Article
- Estimating the mutation load in human genomes.Nature reviews. Genetics · 2015Review
- Genetic association analysis under complex survey sampling: the Hispanic Community Health Study/Study of Latinos.American journal of human genetics · 2014Article
- A genome-wide association study of prostate cancer in West African men.Human genetics · 2014Article
- Adjusting for population stratification in a fine scale with principal components and sequencing data.Genetic epidemiology · 2013Article
- Inference of historical migration rates via haplotype sharing.Bioinformatics (Oxford, England) · 2013Article
- Special considerations in prognostic research in cancer involving genetic polymorphisms.BMC medicine · 2013Review
- The GenoChip: a new tool for genetic anthropology.Genome biology and evolution · 2013Article
- Length distributions of identity by descent reveal fine-scale demographic history.American journal of human genetics · 2012Article
- The great human expansion.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Manifold learning for human population structure studies.PloS one · 2012Article
- Assessing the accuracy and power of population genetic inference from low-pass next-generation sequencing data.Frontiers in genetics · 2012Article
- Cryptic distant relatives are common in both isolated and cosmopolitan genetic samples.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Fine-scale population structure characterizes most continents and is especially pronounced in non-cosmopolitan populations. Roughly half of the world's population remains non-cosmopolitan and even populations within cities often assort along ethnic and linguistic categories. Barriers to random mating can be ecologically extreme, such as the Sahara Desert, or cultural, such as the Indian caste system. In either case, subpopulations accumulate genetic differences if the barrier is maintained over multiple generations. Genome-wide polymorphism data, initially with only a few hundred autosomal microsatellites, have clearly established differences in allele frequency not only among continental regions, but also within continents and within countries. We review recent evidence from the analysis of genome-wide polymorphism data for genetic boundaries delineating human population structure and the main demographic and genomic processes shaping variation, and discuss the implications of population structure for the distribution and discovery of disease-causing genetic variants, in the light of the imminent availability of sequencing data for a multitude of diverse human genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.