ArticleThe Journal of biological chemistry2010
Synergistic effect of retinoic acid and cytokines on the regulation of glial fibrillary acidic protein expression.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Retinoic acid attenuates ischemic injury-induced activation of glial cells and inflammatory factors in a rat stroke model.PloS one · 2024Article
- Novel model of cortical-meningeal organoid co-culture system improves human cortical brain organoid cytoarchitecture.Scientific reports · 2023Article
- Article
- Potential of Multiscale Astrocyte Imaging for Revealing Mechanisms Underlying Neurodevelopmental Disorders.International journal of molecular sciences · 2021Review
- Towards genomic database of Alexander disease to identify variations modifying disease phenotype.Scientific reports · 2019Article
- Developmental Exposure of Mice to T-2 Toxin Increases Astrocytes and Hippocampal Neural Stem Cells Expressing Metallothionein.Neurotoxicity research · 2019Article
- JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells.In vitro cellular & developmental biology. Animal · 2017Article
- Vitamin A deficiency impairs spatial learning and memory: the mechanism of abnormal CBP-dependent histone acetylation regulated by retinoic acid receptor alpha.Molecular neurobiology · 2015Article
- Nanofiber-mediated release of retinoic acid and brain-derived neurotrophic factor for enhanced neuronal differentiation of neural progenitor cells.Drug delivery and translational research · 2015Article
- Regulation and dysregulation of astrocyte activation and implications in tumor formation.Cellular and molecular life sciences : CMLS · 2013Review
- Interaction of JAK with steroid receptor function.JAK-STAT · 2013Review
- p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1.Stem cells and development · 2013Article
- c-Jun N-terminal kinase controls a negative loop in the regulation of glial fibrillary acidic protein expression by retinoic acid.Neuroscience · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glial fibrillary acidic protein (GFAP) is the main astroglial marker during astrogliogenesis, but it is also expressed in other cell types, including neural stem cells and old neurons. Activation of the JAK/STAT pathway by the IL-6 family of cytokines is the canonical pathway regulating GFAP expression, whereas retinoic acid is thought to be the only inducer of GFAP to operate independently of this pathway. Here, we show that retinoic acid receptor α not only links retinoic acid signaling to the canonical cytokine-stimulated pathway leading to GFAP expression but that it also plays a key role in the synergistic actions of retinoic acid and cytokines on this pathway. Cytokines both potentiate retinoic acid receptor α expression and enhance its binding to DNA and to the Stat3-p300/CBP-Smad transcriptional complex, the cornerstone of the canonical pathway. PI3K is upstream to all the key events leading to the expression of GFAP. Our results give new insights about the role of retinoic acid signaling in GFAP expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.