ArticleGenetics2010
The genetic basis for male x female interactions underlying variation in reproductive phenotypes of Drosophila.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 67 citations in OpenAlex.
- Female genetic variation controlling timing of mating plug ejection inbioRxiv : the preprint server for biology · 2026Article
- Long-sperm precedence and other cryptic female choices in Drosophila melanogaster.Evolution; international journal of organic evolution · 2025Article
- Genetic Variation in Male Mate Choice for Large Females inEcology and evolution · 2025Article
- A predominant role of genotypic variation in both expression of sperm competition genes and paternity success inProceedings. Biological sciences · 2023Article
- Social group composition modulates the role of last male sperm precedence in post-copulatory sexual selection.Journal of evolutionary biology · 2023Article
- Octopaminergic/tyraminergic Tdc2 neurons regulate biased sperm usage in female Drosophila melanogaster.Genetics · 2022Article
- The life history ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Population differences and domestication effects on mating and remating frequencies in Queensland fruit fly.Scientific reports · 2022Article
- She's got nerve: roles of octopamine in insect female reproduction.Journal of neurogenetics · 2021Review
- Sex ratio and the evolution of aggression in fruit flies.Proceedings. Biological sciences · 2021Article
- ThePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Interactions between the microbiome and mating influence the female's transcriptional profile in Drosophila melanogaster.Scientific reports · 2020Article
- How female × male and male × male interactions influence competitive fertilization inEvolution letters · 2020Article
- Quantitative proteomics reveals rapid divergence in the postmating response of female reproductive tracts among sibling species.Proceedings. Biological sciences · 2020Article
- Post-ejaculatory modifications to sperm (PEMS).Biological reviews of the Cambridge Philosophical Society · 2020Review
- TheG3 (Bethesda, Md.) · 2020Article
- Structural variation inRoyal Society open science · 2020Article
- Female Genetic Contributions to Sperm Competition inGenetics · 2019Article
- Conspecific sperm precedence is reinforced, but postcopulatory sexual selection weakened, in sympatric populations of Drosophila.Proceedings. Biological sciences · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In Drosophila, where females mate multiply, sperm competition contributes strongly to fitness variability among males. Males transfer "Acp" seminal proteins to females during mating, and these proteins influence the outcome of sperm competition. Because Acps function within the female, male proteins can directly interact with female molecules in a manner that affects reproductive fitness. Here we begin to dissect the genetic architecture of male×female interactions underlying reproductive phenotypes important to sperm competition. By utilizing chromosome extraction lines, we demonstrate that the third and X chromosomes each have large effects on fertility phenotypes, female remating rate, and the sperm competition parameter, P1. Strikingly, the third and X chromosomes harbor genetic variation that gives rise to strong male×female interactions that modulate female remating rate and P1. Encoded on these chromosomes are, respectively, sex peptide (SP) and sex peptide receptor (SPR), the only pair of physically interacting male Acp and female receptor known. We identified several intriguing allelic interactions between SP and SPR. The results of this study begin to elucidate the complex genetic architecture of reproductive and sperm competition phenotypes and have significant implications for the evolution of male and female characters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.