Trial reportStroke2010
The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST): stenting versus carotid endarterectomy for carotid disease.
Trial report in Stroke, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00004732 (Carotid Revascularization Endarterectomy Versus Stenting Trial), which is not on this map. Cited by 104 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)
Who cites it
104 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Hyperacute stenting and angioplasty for acute extracranial non-tandem internal carotid artery strokes within the first 48 h: A 20-year experience and a systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Pooled it
- Role of carotid duplex in the assessment of carotid artery restenosis after endarterectomy or stenting.Frontiers in neurology · 2023Pooled it
- Treatment of the Carotid In-stent Restenosis: A Systematic Review.Frontiers in neurology · 2021Pooled it
- The Efficacy of Transcarotid Artery Revascularization With Flow Reversal System Compared to Carotid Endarterectomy: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Use of Protamine for Anticoagulation During Carotid Endarterectomy: A Meta-analysis.JAMA surgery · 2016Pooled it
- Pooled it
- Casper vs. Closed-Cell Stent : Carotid Artery Stenting Randomized Trial.Clinical neuroradiology · 2021Trial
- Does Antiplatelet Therapy during Bridging Thrombolysis Increase Rates of Intracerebral Hemorrhage in Stroke Patients?PloS one · 2017Trial
- Influence of carotid artery stenting on cognition of elderly patients with severe stenosis of the internal carotid artery.Medical science monitor : international medical journal of experimental and clinical research · 2014Trial
- Association of cerebrovascular center volume with patient outcomes.Neurosurgical review · 2026Review
- Article
- Carotid Artery Stenting Outcomes in Comprehensive Stroke Hospitals (CASSH): A Prospective Multicenter Study.Stroke (Hoboken, N.J.) · 2026Article
- Device use trends in neuroendovascular procedures in the United States from 2015 to 2020.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Early Clinical Experience with Carotid Artery Stenting for Internal Carotid Artery Stenosis Using the Protcas GW Protection System.Journal of neuroendovascular therapy · 2026Article
- Changing Trends in Carotid Revascularization in Australia: A Nationwide Study Over 30 Years.ANZ journal of surgery · 2025Article
- Sex-Related Differences in Early In-Hospital Outcome (Technical Success and Complications) of Carotid Artery Stenting and Risk Factors of Carotid Artery Stenosis.Diseases (Basel, Switzerland) · 2025Article
- Focal Hypoperfusion on Baseline Perfusion-Weighted MRI and the Risk of Subsequent Cerebrovascular Events in Patients With TIA.Neurology · 2025Article
- Age-Related Anatomical Changes in Carotid Artery Stenosis and Its Impact on Postoperative Complications in Stenting and Endarterectomy.CNS neuroscience & therapeutics · 2025Article
- Management of plaque protrusion in transcarotid artery revascularization with stent-in-stent technique.Journal of vascular surgery cases and innovative techniques · 2025Article
- Association of Plaque Characteristics With New Ischemic Lesions After Carotid Artery Stenting.CNS neuroscience & therapeutics · 2025Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
background and purposeCarotid artery stenosis causes up to 10% of all ischemic strokes. Carotid endarterectomy (CEA) was introduced as a treatment to prevent stroke in the early 1950s. Carotid stenting (CAS) was introduced as a treatment to prevent stroke in 1994.
methodsThe Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is a randomized trial with blinded end point adjudication. Symptomatic and asymptomatic patients were randomized to CAS or CEA. The primary end point was the composite of any stroke, myocardial infarction, or death during the periprocedural period and ipsilateral stroke thereafter, up to 4 years.
resultsThere was no significant difference in the rates of the primary end point between CAS and CEA (7.2% versus 6.8%; hazard ratio, 1.11; 95% CI, 0.81 to 1.51; P=0.51). Symptomatic status and sex did not modify the treatment effect, but an interaction with age and treatment was detected (P=0.02). Outcomes were slightly better after CAS for patients aged <70 years and better after CEA for patients aged >70 years. The periprocedural end point did not differ for CAS and CEA, but there were differences in the components, CAS versus CEA (stroke 4.1% versus 2.3%, P=0.012; and myocardial infarction 1.1% versus 2.3%, P=0.032).
conclusionsIn CREST, CAS and CEA had similar short- and longer-term outcomes. During the periprocedural period, there was higher risk of stroke with CAS and higher risk of myocardial infarction with CEA. Clinical Trial Registration-www.clinicaltrials.gov. Unique identifier: NCT00004732.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.