ArticleCirculation2010
Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community.
Article in Circulation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04688177 (The Association of Cigarette Smoking on Exercise Capacity and Skeletal Muscle Function in Taiwan Adult Smokers), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Association of Cigarette Smoking on Exercise Capacity and Skeletal Muscle Function in Taiwan Adult Smokers
Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Endothelial protein C receptor promotes retinal neovascularization through heme catabolism.Nature communications · 2025Article
- The association of exhaled carbon monoxide with atrial fibrillation and left atrial size in the Framingham Heart Study.American heart journal plus : cardiology research and practice · 2024Article
- Pollution and cardiovascular health: A contemporary review of morbidity and implications for planetary health.American heart journal plus : cardiology research and practice · 2023Review
- Association of exhaled carbon monoxide with risk of cardio-cerebral-vascular disease in the China Kadoorie Biobank cohort study.Scientific reports · 2020Article
- Association of Exhaled Carbon Monoxide With Ideal Cardiovascular Health, Circulating Biomarkers, and Incidence of Heart Failure in the Framingham Offspring Study.Journal of the American Heart Association · 2020Article
- Biomarkers of exposure to new and emerging tobacco delivery products.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Let's Be Blunt: Consumption Methods Matter Among Black Marijuana Smokers.Journal of studies on alcohol and drugs · 2016Article
- Associations of Exhaled Carbon Monoxide and Fractional Exhaled Nitric Oxide with Metabolic Syndrome: A Cohort Study.Scientific reports · 2016Article
- Article
- Haeme oxygenase signalling pathway: implications for cardiovascular disease.European heart journal · 2015Review
- The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning.British journal of pharmacology · 2015Review
- ENDOGENOUS CARBON MONOXIDE CONCENTRATION IN BLOOD ELEVATES IN ACUTE CORONARY SYNDROME OF NONSMOKER POPULATION.Fukushima journal of medical science · 2015Article
- Smoking Status Effect on Inflammatory Markers in a Randomized Trial of Current and Former Heavy Smokers.International journal of inflammation · 2015Article
- Friend or foe? Carbon monoxide and the mitochondria.Frontiers in physiology · 2015Article
- Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes.European heart journal · 2014Observational
- Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications.Journal of exposure science & environmental epidemiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEndogenous carbon monoxide (CO) at physiological concentrations is cytoprotective, whereas excess levels reflect underlying oxidative stress, inflammation, and vascular pathology and portend adverse clinical sequelae. However, the relation of exhaled CO to metabolic/vascular risk in the community is unknown. METHODS AND
resultsWe related exhaled CO, a surrogate measure of blood CO concentration, to the risk of developing new-onset metabolic syndrome and incident cardiovascular disease following 14 943 routine examinations (4139 unique participants; mean age, 46 years, 53% women) in the Framingham Heart Study. Baseline exhaled CO was associated with the presence of cardiometabolic risk factors (including smoking) and prevalent metabolic syndrome (odds ratio, 1.09 per log CO; 95% confidence interval, 1.02 to 1.17; P=0.01). During up to 4 years of follow-up, 1458 participants developed new-onset metabolic syndrome, and 416 experienced a first cardiovascular disease event. Compared with individuals in the lowest quartile of exhaled CO, those in the highest quartile were more likely to develop metabolic syndrome (odds ratio, 1.48; 95% confidence interval, 1.25 to 1.76; P<0.0001) and cardiovascular disease events (hazard ratio, 1.66; 95% confidence interval, 1.14 to 2.40; P=0.008) in multivariable analyses that included adjustment for smoking status.
conclusionIn our community-based sample, higher exhaled CO levels predicted the development of metabolic syndrome and future cardiovascular disease events, underscoring the importance of this endogenous second messenger in the pathogenesis of metabolic and vascular risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.