ArticleMolecular and cellular biology2010
Why Dom34 stimulates growth of cells with defects of 40S ribosomal subunit biosynthesis.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- The ASC-1 Complex Disassembles Collided Ribosomes.Molecular cell · 2020Article
- Disruption in iron homeostasis and impaired activity of iron-sulfur cluster containing proteins in the yeast model of Shwachman-Diamond syndrome.Cell & bioscience · 2020Article
- Does functional specialization of ribosomes really exist?RNA (New York, N.Y.) · 2019Review
- Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.PLoS genetics · 2019Article
- Interactions between the mRNA and Rps3/uS3 at the entry tunnel of the ribosomal small subunit are important for no-go decay.PLoS genetics · 2018Article
- Roadblocks and resolutions in eukaryotic translation.Nature reviews. Molecular cell biology · 2018Review
- Translation of poly(A) tails leads to precise mRNA cleavage.RNA (New York, N.Y.) · 2017Article
- Dom34 Links Translation to Protein O-mannosylation.PLoS genetics · 2016Article
- Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets.Cell reports · 2016Article
- Distinct types of translation termination generate substrates for ribosome-associated quality control.Nucleic acids research · 2016Article
- Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3'UTRs In Vivo.Cell · 2015Article
- Asc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats.RNA (New York, N.Y.) · 2015Article
- pelo is required for high efficiency viral replication.PLoS pathogens · 2014Article
- Article
- Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress.The EMBO journal · 2014Article
- Active regulator of SIRT1 is required for ribosome biogenesis and function.Nucleic acids research · 2013Article
- Recent structural studies on Dom34/aPelota and Hbs1/aEF1α: important factors for solving general problems of ribosomal stall in translation.Biophysics (Nagoya-shi, Japan) · 2013Review
- Surveillance pathways rescuing eukaryotic ribosomes lost in translation.Nature reviews. Molecular cell biology · 2012Review
- A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits.Cell · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A set of genome-wide screens for proteins whose absence exacerbates growth defects due to pseudo-haploinsufficiency of ribosomal proteins in Saccharomyces cerevisiae identified Dom34 as being particularly important for cell growth when there is a deficit of 40S ribosomal subunits. In contrast, strains with a deficit of 60S ribosomal proteins were largely insensitive to the loss of Dom34. The slow growth of cells lacking Dom34 and haploinsufficient for a protein of the 40S subunit is caused by a severe shortage of 40S subunits available for translation initiation due to a combination of three effects: (i) the natural deficiency of 40S subunits due to defective synthesis, (ii) the sequestration of 40S subunits due to the large accumulation of free 60S subunits, and (iii) the accumulation of ribosomes "stuck" in a distinct 80S form, insensitive to the Mg(2+) concentration, and at least temporarily unavailable for further translation. Our data suggest that these stuck ribosomes have neither mRNA nor tRNA. We postulate, based on our results and on previously published work, that the stuck ribosomes arise because of the lack of Dom34, which normally resolves a ribosome stalled due to insufficient tRNAs, to structural problems with its mRNA, or to a defect in the ribosome itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.