ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011
Rapid activation of the bivalent gene Sox21 requires displacement of multiple layers of gene-silencing machinery.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development.Genes & diseases · 2023Review
- SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways.eLife · 2021Article
- FERTILIZATION-INDEPENDENT SEED-Polycomb Repressive Complex 2 Plays a Dual Role in Regulating Type I MADS-Box Genes in Early Endosperm Development.Plant physiology · 2018Article
- Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain.Frontiers in molecular neuroscience · 2018Article
- Article
- The Role of Gammaherpesviruses in Cancer Pathogenesis.Pathogens (Basel, Switzerland) · 2016Review
- Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene.Oncotarget · 2015Article
- Sox21 regulates the progression of neuronal differentiation in a dose-dependent manner.Developmental biology · 2015Article
- Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells.Nucleic acids research · 2013Article
- Modeling the dynamics of bivalent histone modifications.PloS one · 2013Article
- Systems biology provides new insights into the molecular mechanisms that control the fate of embryonic stem cells.Journal of cellular physiology · 2012Review
- A proteomic study of TAR-RNA binding protein (TRBP)-associated factors.Cell & bioscience · 2011Article
- Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes.PloS one · 2010Article
- The molecular circuitry underlying pluripotency in embryonic stem cells.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The rapid formation of numerous tissues during development is highly dependent on the swift activation of key developmental regulators. Recent studies indicate that many key regulatory genes are repressed in embryonic stem cells (ESCs), yet poised for rapid activation due to the presence of both activating (H3K4 trimethylation) and repressive (H3K27 trimethylation) histone modifications (bivalent genes). However, little is known about bivalent gene regulation. In this study, we investigated the regulation of the bivalent gene Sox21, which is activated rapidly when ESCs differentiate in response to increases in Sox2. Chromatin immunoprecipitation demonstrated that prior to differentiation, the Sox21 gene is bound by a complex array of repressive and activating transcriptional machinery. Upon activation, all identified repressive machinery and histone modifications associated with the gene are lost, but the activating modifications and transcriptional machinery are retained. Notably, these changes do not occur when ESCs differentiate in response to retinoic acid. Moreover, ESCs lacking a functional PRC2 complex fail to activate this gene, apparently due to its association with other repressive complexes. Together, these findings suggest that bivalent genes, such as Sox21, are silenced by a complex set of redundant repressive machinery, which exit rapidly in response to appropriate differentiation signals.
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