ArticleThe Journal of physiology2010
Attenuated exercise induced hyperaemia with age: mechanistic insight from passive limb movement.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Improved vascular function and functional capacity following l-citrulline administration in patients with heart failure with preserved ejection fraction: a single-arm, open-label, prospective pilot study.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Leg vascular function with advancing age in men: the impact of physical activity and endurance exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Acute sympathetic activation blunts the hyperemic and vasodilatory response to passive leg movement in young healthy males.Physiological reports · 2025Article
- Acute sympathetic activation blunts the hyperemic and vasodilatory response to passive leg movement.Research square · 2024Article
- Influence of blood lactate variations and passive exercise on cardiac responses.Journal of physical therapy science · 2024Article
- Exercise-induced skeletal muscle angiogenesis: impact of age, sex, angiocrines and cellular mediators.European journal of applied physiology · 2023Review
- Pharmacological modulation of adrenergic tone alters the vasodilatory response to passive leg movement in young but not in old adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Effect of Lower Limb Venous Dilation on the Autonomic Cardiac Response among Healthy Young Men.Healthcare (Basel, Switzerland) · 2023Article
- Reliability of the passive leg movement assessment of vascular function in men.Experimental physiology · 2022Article
- Muscle stiffening is associated with muscle mechanoreflex-mediated cardioacceleration.European journal of applied physiology · 2022Article
- Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction.Hypertension (Dallas, Tex. : 1979) · 2021Article
- The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide.American journal of physiology. Heart and circulatory physiology · 2021Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Influence of dietary inorganic nitrate on blood pressure and vascular function in hypertension: prospective implications for adjunctive treatment.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Physiological Impact and Clinical Relevance of Passive Exercise/Movement.Sports medicine (Auckland, N.Z.) · 2019Review
- Delineating the age-related attenuation of vascular function: Evidence supporting the efficacy of the single passive leg movement as a screening tool.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- The effect of the speed and range of motion of movement on the hyperemic response to passive leg movement.Physiological reports · 2019Article
- Altered vascular function in chronic kidney disease: evidence from passive leg movement.Physiological reports · 2019Article
- Exercise and Cardioprotection: A Natural Defense Against Lethal Myocardial Ischemia-Reperfusion Injury and Potential Guide to Cardiovascular Prophylaxis.Journal of cardiovascular pharmacology and therapeutics · 2019Review
- Passive limb movement intervals results in repeated hyperemic responses in those with paraplegia.Spinal cord · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
The influence of age on the central and peripheral contributors to exercise-induced hyperaemia is unclear. Utilizing a reductionist approach, we compared the peripheral and central haemodynamic responses to passive limb movement (exercise without an increase in metabolism) in 11 old (71 ± 9 years of age S.D.) and 11 young (24 ± 2 years of age) healthy subjects. Cardiac output (CO), heart rate (HR), stroke volume (SV), mean arterial pressure (MAP), and femoral blood flow of the passively moved and control legs were evaluated second-by-second during 2 min of passive knee extension at a rate of 1 Hz. Compared to the young, the old group exhibited a significantly attenuated increase in HR (7 ± 4% vs. 13 ± 7% S.D.), CO (10 ± 6% vs. 18 ± 8%) and femoral blood flow in the passively moved (123 ± 55% vs. 194 ± 57%) and control legs (47 ± 43% vs. 77 ± 96%). In addition, the change in vascular conductance in the passively moving limb was also significantly attenuated in the old (2.4 ± 1.2 ml min(-1) mmHg(-1)) compared to the young (4.3 ± 1.7 ml min(-1) mmHg(-1)). In both groups all main central and peripheral changes that occurred at the onset of passive knee extension were transient, lasting only 45 s. In a paradigm where metabolism does not play a role, these data reveal that both central and peripheral haemodynamic mechanisms are likely to be responsible for the 30% reduction in exercise-induced hyperaemia with age.
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