ArticleThe Journal of physiology2010
Monosynaptic excitatory inputs to spinal lamina I anterolateral-tract-projecting neurons from neighbouring lamina I neurons.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Dual-frequency spinal cord stimulation increases responder rates for treatment of neuropathic pain.Pain · 2026Article
- An electrophysiologist's guide to dorsal horn excitability and pain.Frontiers in cellular neuroscience · 2025Review
- Lateral lamina V projection neuron axon collaterals connect sensory processing across the dorsal horn of the mouse spinal cord.Scientific reports · 2024Article
- Model-based analysis of subthreshold mechanisms of spinal cord stimulation for pain.Journal of neural engineering · 2023Article
- An optimization framework for targeted spinal cord stimulation.Journal of neural engineering · 2023Article
- Quantitative spatial analysis reveals that the local axons of lamina I projection neurons and interneurons exhibit distributions that predict distinct roles in spinal sensory processing.The Journal of comparative neurology · 2022Article
- Presynaptic Interactions between Trigeminal and Cervical Nociceptive Afferents Supplying Upper Cervical Lamina I Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neural Recruitment During Conventional, Burst, and 10-kHz Spinal Cord Stimulation for Pain.The journal of pain · 2022Article
- Spinal Excitatory Dynorphinergic Interneurons Contribute to Burn Injury-Induced Nociception Mediated by Phosphorylated Histone 3 at Serine 10 in Rodents.International journal of molecular sciences · 2021Article
- Projection Neuron Axon Collaterals in the Dorsal Horn: Placing a New Player in Spinal Cord Pain Processing.Frontiers in physiology · 2020Review
- Distinct mechanisms of signal processing by lamina I spino-parabrachial neurons.Scientific reports · 2019Article
- Spatial organization of activity evoked by focal stimulation within the rat spinal dorsal horn as visualized by voltage-sensitive dye imaging in the slice.Journal of neurophysiology · 2019Article
- Agmatine preferentially antagonizes GluN2B-containing N-methyl-d-aspartate receptors in spinal cord.Journal of neurophysiology · 2019Article
- MRI characteristics for "phantom" scratching in canine syringomyelia.BMC veterinary research · 2017Article
- N3DFix: an Algorithm for Automatic Removal of Swelling Artifacts in Neuronal Reconstructions.Neuroinformatics · 2017Article
- Article
- Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control.Journal of neurophysiology · 2015Article
- Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses.The Journal of physiology · 2014Article
- Three-dimensional organization of local excitatory and inhibitory inputs to neurons in laminae III-IV of the spinal dorsal horn.The Journal of physiology · 2013Article
- Axon diversity of lamina I local-circuit neurons in the lumbar spinal cord.The Journal of comparative neurology · 2013Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal lamina I receives nociceptive primary afferent input to project through diverse ascending pathways, including the anterolateral tract (ALT). Large projection neurons (PNs) form only a few per cent of the cell population in this layer, and little is known about their local input from other lamina I neurons. We combined single-cell imaging in the isolated spinal cord, paired recordings, 3-D reconstructions of biocytin-labelled neurons and computer simulations to study the monosynaptic input to large ALT-PNs from neighbouring (somata separated by less than 80 μm) large lamina I neurons. All 11 connections identified were excitatory. We have found that an axon of a presynaptic neuron forms multiple synapses on an ALT-PN, and both Ca(2+)-permeable and Ca(2+)-impermeable AMPA receptors are involved in transmission. The monosynaptic EPSC latencies (1-12 ms) are determined by both post- and presynaptic factors. The postsynaptic delay, resulting from the electrotonic EPSC propagation in the dendrites of an ALT-PN, could be 4 ms at most. The presynaptic delay, caused by the spike propagation in a narrow highly branched axon of a local-circuit neuron, can be about 10 ms for neighbouring ALT-PNs and longer for more distant neurons. In many cases, the EPSPs evoked by release from a lamina I neuron were sufficient to elicit a spike in an ALT-PN. Our data show that ALT-PNs can receive input from both lamina I local-circuit neurons and other ALT-PNs. We suggest that lamina I is a functionally interconnected layer. The intralaminar network described here can amplify the overall output from the principal spinal nociceptive projection area.
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