ArticleProceedings of the National Academy of Sciences of the United States of America2010
Unraveling electronic energy transfer in single conjugated polyelectrolytes encapsulated in lipid vesicles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Surface-Induced Photophysical Enhancement of Conjugated Polyelectrolytes on Cellulose Nanocrystals: A Single-Particle Study.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Electronic polymers in lipid membranes.Scientific reports · 2015Article
- Stepwise growth of surface-grafted DNA nanotubes visualized at the single-molecule level.Nature chemistry · 2015Article
- Single-molecule FRET studies of HIV TAR-DNA hairpin unfolding dynamics.The journal of physical chemistry. B · 2014Article
- Role of conformational dynamics in α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor partial agonism.The Journal of biological chemistry · 2012Article
- Site-specific fluorescent labeling and oriented immobilization of a triple mutant of CYP3A4 via C64.Bioconjugate chemistry · 2012Article
- Using polymer conformation to control architecture in semiconducting polymer/viral capsid assemblies.ACS nano · 2011Article
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Authors and funding
4 authors.
Funding
Abstract
A method for the study of conjugated polyelectrolyte (CPE) photophysics in solution at the single-molecule level is described. Extended observation times of single polymer molecules are enabled by the encapsulation of the CPEs within 200-nm lipid vesicles, which are in turn immobilized on a surface. When combined with a molecular-level visualization of vesicles and CPE via cryo-transmission electron microscopy, these single-molecule spectroscopy studies on CPEs enable us to directly correlate the polymer conformation with its spectroscopic features. These studies are conducted with poly[5-methoxy-2-(3-sulfopropoxy)-1,4-phenylene-vinylene] (MPS-PPV, a negatively charged CPE), when encapsulated in neutral and in negatively charged lipid vesicles. MPS-PPV exists as a freely diffusing polymer when confined in negatively charged vesicles. Individual MPS-PPV molecules adopt a collapsed-chain conformation leading to efficient energy migration over multiple chromophores. Both the presence of stepwise photobleaching in fluorescence intensity-time trajectories and emission from low-energy chromophores along the chain are observed. These results correlate with the amplified sensing potential reported for MPS-PPV in aqueous solution. When confined within neutral vesicles, single MPS-PPV molecules adopt an extended conformation upon insertion in the lipid bilayer. In this case emission arises from multiple chromophores within the isolated polymer chains, leading to an exponential decay of the intensity over time and a broad blue-shifted emission spectrum.
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