ArticleProceedings of the National Academy of Sciences of the United States of America2010
Right-handed double-helix ultrashort DNA yields chiral nematic phases with both right- and left-handed director twist.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 114 citations in OpenAlex.
- Fibers and Double-Layered Tubes Formed From a Single Self-Complementary DNA Oligonucleotide.Angewandte Chemie (International ed. in English) · 2026Article
- Elucidating chirality transfer in liquid crystals of viruses.Nature materials · 2024Article
- Twisted Structures in Natural and Bioinspired Molecules: Self-Assembly and Propagation of Chirality Across Multiple Length Scales.ACS omega · 2023Review
- Cellulose: A Review of Water Interactions, Applications in Composites, and Water Treatment.Chemical reviews · 2023Review
- Chiral emergence in multistep hierarchical assembly of achiral conjugated polymers.Nature communications · 2022Article
- Deconstruction and Reassembly of Renewable Polymers and Biocolloids into Next Generation Structured Materials.Chemical reviews · 2021Review
- Chiral Systems Made from DNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- DNA Origami Nano-Sheets and Nano-Rods Alter the Orientational Order in a Lyotropic Chromonic Liquid Crystal.Nanomaterials (Basel, Switzerland) · 2020Article
- Free energy of conformational isomers: The case of gapped DNA duplexes.The European physical journal. E, Soft matter · 2019Article
- Speeding up Monte Carlo simulation of patchy hard cylinders.The European physical journal. E, Soft matter · 2018Article
- Confinement-induced liquid crystalline transitions in amyloid fibril cholesteric tactoids.Nature nanotechnology · 2018Article
- Lyotropic Liquid Crystal Phases from Anisotropic Nanomaterials.Nanomaterials (Basel, Switzerland) · 2017Review
- Molecular engineering of chiral colloidal liquid crystals using DNA origami.Nature materials · 2017Article
- Non-linear optical measurement of the twist elastic constant in thermotropic and DNA lyotropic chiral nematics.Scientific reports · 2017Article
- Entropy-driven formation of chiral nematic phases by computer simulations.Nature communications · 2016Article
- Measurement of the Nucleus Area and Nucleus/Cytoplasm and Mitochondria/Nucleus Ratios in Human Colon Tissues by Dual-Colour Two-Photon Microscopy Imaging.Scientific reports · 2015Article
- Evidence of liquid crystal-assisted abiotic ligation of nucleic acids.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2015Article
- Equilibrium gels of trivalent DNA-nanostars: Effect of the ionic strength on the dynamics.The European physical journal. E, Soft matter · 2015Article
- Topological friction strongly affects viral DNA ejection.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Helical structure determines different susceptibilities of dsDNA, dsRNA, and tsDNA to counterion-induced condensation.Biophysical journal · 2013Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concentrated solutions of duplex-forming DNA oligomers organize into various mesophases among which is the nematic (N(∗)), which exhibits a macroscopic chiral helical precession of molecular orientation because of the chirality of the DNA molecule. Using a quantitative analysis of the transmission spectra in polarized optical microscopy, we have determined the handedness and pitch of this chiral nematic helix for a large number of sequences ranging from 8 to 20 bases. The B-DNA molecule exhibits a right-handed molecular double-helix structure that, for long molecules, always yields N(∗) phases with left-handed pitch in the μm range. We report here that ultrashort oligomeric duplexes show an extremely diverse behavior, with both left- and right-handed N(∗) helices and pitches ranging from macroscopic down to 0.3 μm. The behavior depends on the length and the sequence of the oligomers, and on the nature of the end-to-end interactions between helices. In particular, the N(∗) handedness strongly correlates with the oligomer length and concentration. Right-handed phases are found only for oligomers shorter than 14 base pairs, and for the sequences having the transition to the N(∗) phase at concentration larger than 620 mg/mL. Our findings indicate that in short DNA, the intermolecular double-helical interactions switch the preferred liquid crystal handedness when the columns of stacked duplexes are forced at high concentrations to separations comparable to the DNA double-helix pitch, a regime still to be theoretically described.
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