ArticleProceedings of the National Academy of Sciences of the United States of America2010
FERONIA receptor-like kinase regulates RHO GTPase signaling of root hair development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 313 papers.
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Who cites it
313 citing papers in PubMed, 642 citations in OpenAlex.
- Review
- Mechanical constraint causes lower turgor, thicker walls, and faster growth in Arabidopsis root hairs.Plant physiology · 2026Article
- Endogenous RALF peptide function is required for powdery mildew host colonization.The New phytologist · 2026Article
- FERONIA Modulates Translational Buffering Capacity of Ribosome-Associated Gene Module in Salt-Stressed Tomato Roots.Plants (Basel, Switzerland) · 2026Article
- Dual role of the receptor kinase FERONIA in regulating tissue mechanics and growth.Science advances · 2026Article
- Reactive oxygen species in plants: spatiotemporal organization, redox signaling, and stress adaptation.Planta · 2026Review
- Ancient peptide-redox signalling underlies sperm motility in Marchantia.Nature plants · 2026Article
- Multiomics analyses of mutants for Marchantia polymorpha FERONIA and MARIS reveal a link between cell wall integrity and abscisic acid responses.Plant & cell physiology · 2026Article
- FERONIA defines intact tissue boundaries through cuticle development.Nature communications · 2026Article
- Crosstalk and reciprocal regulation of phosphorylation and ubiquitination mediated by receptor-like kinases and U-box E3 ligases during plant growth and environmental stress responses.Plant communications · 2026Review
- Genome-wide association study and evolutionary analysis of the CrRLK1L family reveal BnCrRLK1L1_5 as a positive regulator of Sclerotinia sclerotiorum resistance in Brassica napus.BMC plant biology · 2026Article
- Linking Superoxide Production and Scavenging in Plant Development.Plant, cell & environment · 2026Review
- From recognition to response: integrated signaling pathways determining pollen acceptance and rejection in Brassicaceae.The New phytologist · 2026Review
- The OsRALF5-FLR1 Module Regulates Rice Root Development and Provides a Target for Studying Cell-Cell Communication.Rice (New York, N.Y.) · 2026Article
- Terrestrial Plant- and Algal-Derived Biostimulants as Modulators of ROS and Hormone Networks in Crop Abiotic Stress Resilience.Plants (Basel, Switzerland) · 2026Review
- Insights into the roles of RALF peptides and CrRLK1L receptors in fruit ripening.The Plant journal : for cell and molecular biology · 2026Review
- Pan-family pollen signals control an interspecific stigma barrier across Brassicaceae species.Science (New York, N.Y.) · 2026Article
- Memory in the wall: expanding our understanding of the roles of plant cell walls.The New phytologist · 2026Review
- Gene family ofFrontiers in plant science · 2026Article
- The Arabidopsis phosphatase PP2C12 negatively regulates LRX-RALF-FER-mediated cell wall integrity sensing.The EMBO journal · 2026Article
253 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant RHO GTPases (RAC/ROPs) mediate multiple extracellular signals ranging from hormone to stress and regulate diverse cellular processes important for polarized cell growth, differentiation, development, reproduction, and responses to the environment. They shuttle between the GDP-bound inactive state and the GTP-bound activated state and their activation is predominantly mediated by a family of guanine nucleotide exchange factors (GEFs) referred to as ROPGEFs. Using the Arabidopsis ROPGEF1 as bait, we identified members of a receptor-like kinase (RLK) family as potential upstream regulators for RAC/ROP signaling. NADPH oxidase-derived reactive oxygen species (ROS) are emerging as important regulators for growth and development and play a crucial role in mediating RAC/ROP-regulated root hair development, a polarized cell growth process. We therefore screened T-DNA insertion mutants in these RLKs for root hair defects and found that mutations in one of them, At3g51550 encoding the FERONIA (FER) receptor-like kinase, induced severe root hair defects. We show that the fer phenotypes correlated with reduced levels of active RAC/ROPs and NADPH oxidase-dependent, auxin-regulated ROS accumulation in roots and root hairs and that up-regulating RAC/ROP signaling in fer countered the mutant phenotypes. Taken together, these observations strongly support FER as an upstream regulator for the RAC/ROP-signaled pathway that controls ROS-mediated root hair development. Moreover, FER was pulled down by ROP2 GTPase in a guanine nucleotide-regulated manner implying a dynamic signaling complex involving FER, a ROPGEF, and a RAC/ROP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.