Evidence map›Paper›PMID 20876072›Full record

ReviewTobacco control2010

Nicotine reduction revisited: science and future directions.

Dorothy K Hatsukami, Kenneth A Perkins, Mark G Lesage, David L Ashley, Jack E Henningfield, Neal L Benowitz, Cathy L Backinger, Mitch Zeller

Registry-linked trialAbstract readReview
In one paragraph

Review in Tobacco control, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05320887 (The Impact of Cigarette Nicotine Content, E-Cigarette Nicotine Content and E-Cigarette Flavoring on Smoking Behavior in an Electronic Tobacco Marketplace), which is not on this map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05320887 nacompletednot on this mapstarted 2022, after this paper: background citation

The Impact of Cigarette Nicotine Content, E-Cigarette Nicotine Content and E-Cigarette Flavoring on Smoking Behavior in an Electronic Tobacco Marketplace

TypeinterventionalSponsorWake Forest University Health SciencesRan2022 to 2023Enrolled69ConditionsTobacco UseArmsNormal Nicotine Content Vape with all flavor e-liquids, Normal nicotine content vape with tobacco e-liquids, Low nicotine content vape with all flavor e-liquids, Low nicotine content vape with tobacco e-liquids
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 112 citations in OpenAlex.

  1. Trial
  2. Practical guidance on modeling choices for the virtual twins method.Journal of biopharmaceutical statistics · 2023
    Trial
  3. An Evaluation of Potential Unintended Consequences of a Nicotine Product Standard: A Focus on Drinking History and Outcomes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021
    Trial
  4. Switching to Progressively Reduced Nicotine Content Cigarettes in Smokers With Low Socioeconomic Status: A Double-Blind Randomized Clinical Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021
    Trial
  5. Trial
  6. Trial
  7. Effects of 6-Week Use of Reduced-Nicotine Content Cigarettes in Smokers With and Without Elevated Depressive Symptoms.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Reduced nicotine content cigarettes and nicotine patch.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013
    Trial
  12. Dose-response effects of spectrum research cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013
    Trial
  13. Smoking behavior and exposure to tobacco toxicants during 6 months of smoking progressively reduced nicotine content cigarettes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012
    Trial
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Dorothy K HatsukamiTobacco Use Research Center, University of Minnesota, 717 Delaware St SE, Minneapolis, Minnesota 55414, USA. hatsu001@umn.edu
Kenneth A Perkins
Mark G Lesage
David L Ashley
Jack E Henningfield
Neal L Benowitz
Cathy L Backinger
Mitch Zeller
Pinney Associates (United States)University of Minnesota · USCenters for Disease Control and Prevention · USNational Cancer Institute · USUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

TOBACCO REDUCTION STRATEGIES FOR PATIENTS WITH CARDIAC DISEASEP50DA013333 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HATSUKAMI, DOROTHY K · 1999 to 2008
$16.8M
Determinants of Nicotine Reinforcement Thresholds and Demand Elasticity in RatsR01DA026444 · NIDA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI LESAGE, MARK G · 2009 to 2013
$1.6M
NIDA NIH HHS P50 DA013333NIDA NIH HHS R01 DA026444
6 · The paper itself

Abstract

Regulation of nicotine levels in cigarettes and other tobacco products is now possible with the passage of the Family Smoking Prevention and Tobacco Control Act (FSPTCA) in 2009, giving the US Food and Drug Administration (FDA) authority to regulate tobacco products, and with Articles 9-11 of the WHO Framework Convention on Tobacco Control. Both regulatory approaches allow establishing product standards for tobacco constituents, including nicotine. The FSPTCA does not allow nicotine levels to be decreased to zero, although the FDA has the authority to reduce nicotine yields to very low, presumably non-addicting levels. The proposal to reduce levels of nicotine to a level that is non-addicting was originally suggested in 1994. Reduction of nicotine in tobacco products could potentially have a profound impact on reducing tobacco-related morbidity and mortality. To examine this issue, two meetings were convened in the US with non-tobacco-industry scientists of varied disciplines, tobacco control policymakers and representatives of government agencies. This article provides an overview of the current science in the area of reduced nicotine content cigarettes and key conclusions and recommendations for research and policy that emerged from the deliberations of the meeting members.

Indexed as

NicotineAnimalsGovernment RegulationHealth PolicyHumansNicotianaSmokingSmoking CessationTobacco IndustryTobacco Use DisorderUnited StatesNicotine

Identifiers

PMID20876072
PMCPMC4618689
OpenAlexW2099241769

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.