ArticleDevelopmental biology2011
Internalization of multiple cells during C. elegans gastrulation depends on common cytoskeletal mechanisms but different cell polarity and cell fate regulators.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 43 citations in OpenAlex.
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- Cell lineage-resolved embryonic morphological map reveals signaling associated with cell fate and size asymmetry.Nature communications · 2025Article
- SYS-1/beta-catenin inheritance and regulation by Wnt signaling during asymmetric cell division.Molecular biology of the cell · 2025Article
- Cell-based allometry: an approach for evaluation of complexity in morphogenesis.Quantitative biology (Beijing, China) · 2023Article
- A compound PCP scheme underlies sequential rosettes-based cell intercalation.Development (Cambridge, England) · 2023Article
- Zyxin contributes to coupling between cell junctions and contractile actomyosin networks during apical constriction.PLoS genetics · 2023Article
- SRGP-1/srGAP and AFD-1/afadin stabilize HMP-1/⍺-catenin at rosettes to seal internalization sites following gastrulation in C. elegans.PLoS genetics · 2023Article
- Delineating the mechanisms and design principles ofComputational and structural biotechnology journal · 2022Review
- Epithelial morphogenesis, tubulogenesis and forces in organogenesis.Current topics in developmental biology · 2021Review
- Differential Thresholds of Proteasome Activation Reveal Two Separable Mechanisms of Sensory Organ Polarization inFrontiers in cell and developmental biology · 2021Article
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- Planar Asymmetries in theFrontiers in cell and developmental biology · 2019Article
- The RhoGEF protein Plekhg5 regulates apical constriction of bottle cells during gastrulation.Development (Cambridge, England) · 2018Article
- Cell Division Drives Epithelial Cell Rearrangements during Gastrulation in Chick.Developmental cell · 2016Article
- Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation.Genetics · 2016Article
- Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues.Current topics in membranes · 2015Review
- Apical constriction: themes and variations on a cellular mechanism driving morphogenesis.Development (Cambridge, England) · 2014Review
- The secretory pathway calcium ATPase PMR-1/SPCA1 has essential roles in cell migration during Caenorhabditis elegans embryonic development.PLoS genetics · 2013Article
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2 authors at 1 institution in 1 country.
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Abstract
Understanding the links between developmental patterning mechanisms and force-producing cytoskeletal mechanisms is a central goal in studies of morphogenesis. Gastrulation is the first morphogenetic event in the development of many organisms. Gastrulation involves the internalization of surface cells, often driven by the contraction of actomyosin networks that are deployed with spatial precision-both in specific cells and in a polarized manner within each cell. These cytoskeletal mechanisms rely on different cell fate and cell polarity regulators in different organisms. Caenorhabditis elegans gastrulation presents an opportunity to examine the extent to which diverse mechanisms may be used by dozens of cells that are internalized at distinct times within a single organism. We identified 66 cells that are internalized in C. elegans gastrulation, many of which were not known previously to gastrulate. To gain mechanistic insights into how these cells internalize, we genetically manipulated cell fate, cell polarity and cytoskeletal regulators and determined the effects on cell internalization. We found that cells of distinct lineages depend on common actomyosin-based mechanisms to gastrulate, but different cell fate regulators, and, surprisingly, different cell polarity regulators. We conclude that diverse cell fate and cell polarity regulators control common mechanisms of morphogenesis in C. elegans. The results highlight the variety of developmental patterning mechanisms that can be associated with common cytoskeletal mechanisms in the morphogenesis of an animal embryo.
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