Evidence map›Paper›PMID 20875166›Full record

ReviewMicroscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada2010

Contributions of electron microscopy to understand secretion of immune mediators by human eosinophils.

Rossana C N Melo, Ann M Dvorak, Peter F Weller

Open access · greenAbstract readReview
In one paragraph

Review in Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Exosomes: A Key Piece in Asthmatic Inflammation.International journal of molecular sciences · 2021
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Functions of tissue-resident eosinophils.Nature reviews. Immunology · 2017
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. CCL11 elicits secretion of RNases from mouse eosinophils and their cell-free granules.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Rossana C N MeloLaboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora, UFJF, Juiz de Fora, MG, Brazil. rossana.melo@ufjf.edu.br
Ann M Dvorak
Peter F Weller
Beth Israel Deaconess Medical Center · USHarvard University · US

Funding

CYTOPLASMIC LIPID BODIES OF INFLAMMATORY CELLSR01AI022571 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLER, PETER F · 1985 to 2013
$4.5M
Human Eosinophils: Mechanisms of FunctioningR37AI020241 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLER, PETER F · 2010 to 2019
$4.5M
Airways Eosinophils as Antigen-presenting Cells in AsthmaR01AI051645 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLER, PETER F · 2001 to 2011
$3.8M
HUMAN EOSINOPHILS: MECHANISMS OF FUNCTIONINGR01AI020241 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLER, PETER F · 1985 to 2009
$3.5M
NIAID NIH HHS AI020241NIAID NIH HHS AI022571NIAID NIH HHS AI051645NIAID NIH HHS R01 AI020241NIAID NIH HHS R01 AI022571NIAID NIH HHS R01 AI051645NIAID NIH HHS R37 AI020241
6 · The paper itself

Abstract

Mechanisms governing secretion of proteins underlie the biologic activities and functions of human eosinophils, leukocytes of the innate immune system, involved in allergic, inflammatory, and immunoregulatory responses. In response to varied stimuli, eosinophils are recruited from the circulation into inflammatory foci, where they modulate immune responses through the release of granule-derived products. Transmission electron microscopy (TEM) is the only technique that can clearly identify and distinguish between different modes of cell secretion. In this review, we highlight the advances in understanding mechanisms of eosinophil secretion, based on TEM findings, that have been made over the past years and that have provided unprecedented insights into the functional capabilities of these cells.

Indexed as

CytokinesEosinophilsHumansInflammation MediatorsMicroscopy, ElectronCytokinesInflammation Mediators

Identifiers

PMID20875166
PMCPMC3420811
OpenAlexW2003984174

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.