ArticleJournal of computational biology : a journal of computational molecular cell biology2010
An effective method for detecting gene conversion events in whole genomes.
Article in Journal of computational biology : a journal of computational molecular cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- A Graph-based Goat Pangenome Reveals Structural Variations Involved in Domestication and Adaptation.Molecular biology and evolution · 2024Article
- Gene tree species tree reconciliation with gene conversion.Journal of mathematical biology · 2019Article
- Insights into the evolution of cotton diploids and polyploids from whole-genome re-sequencing.G3 (Bethesda, Md.) · 2013Article
- Duplication and concerted evolution in a master sex determiner under balancing selection.Proceedings. Biological sciences · 2013Article
- Strong purifying selection against gene conversions in the trypsin genes of primates.Human genetics · 2012Article
- Interlocus gene conversion events introduce deleterious mutations into at least 1% of human genes associated with inherited disease.Genome research · 2012Article
- Revealing mammalian evolutionary relationships by comparative analysis of gene clusters.Genome biology and evolution · 2012Article
- Conversion events in gene clusters.BMC evolutionary biology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gene conversion events are often overlooked in analyses of genome evolution. In a conversion event, an interval of DNA sequence (not necessarily containing a gene) overwrites a highly similar sequence. The event creates relationships among genomic intervals that can confound attempts to identify orthologs and to transfer functional annotation between genomes. Here we examine 1,616,329 paralogous pairs of mouse genomic intervals, and detect conversion events in about 7.5% of them. Properties of the putative gene conversions are analyzed, such as the lengths of the paralogous pairs and the spacing between their sources and targets. Our approach is illustrated using conversion events in primate CCL gene clusters. Source code for our program is included in the 3SEQ_2D package, which is freely available at www.bx.psu.edu/miller_lab/ .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.