ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2010
An investigation of candidate regions for association with bipolar disorder.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Purinergic system in psychiatric diseases.Molecular psychiatry · 2018Review
- Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank.Translational psychiatry · 2017Article
- LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.Oncotarget · 2016Article
- Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene.Psychiatric genetics · 2011Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
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Abstract
We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.
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