ArticleJournal of gastrointestinal cancer2012
Potential value of estrogen receptor beta expression in colorectal carcinoma: interaction with apoptotic index.
Article in Journal of gastrointestinal cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Sex and gender-oriented colorectal cancer screening: a consensus study from the AIOM- GISEG working group.Frontiers in oncology · 2026Article
- To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity.Exposure and health · 2023Review
- Genetic Variation and Mendelian Randomization Approaches.Advances in experimental medicine and biology · 2022Article
- Estrogen Receptors in Colorectal Cancer: Facts, Novelties and Perspectives.Current oncology (Toronto, Ont.) · 2021Article
- Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases.International journal of molecular sciences · 2021Review
- Review
- DNA methylation in the upstream CpG island of the GPER locus and its relationship with GPER expression in colon cancer cell lines.Molecular biology reports · 2020Article
- Effect of 5-aza-2'-deoxycytidine on Estrogen Receptor Alpha/Beta and DNA Methyltransferase 1 Genes Expression, Apoptosis Induction, and Cell Growth Prevention of the Colon Cancer HT 29 Cell Line.International journal of preventive medicine · 2020Article
- A novel long non-coding RNA from the HOXA6-HOXA5 locus facilitates colon cancer cell growth.BMC cancer · 2019Article
- Expression and Prognostic Value of Oestrogen Receptor Beta in Colorectal Cancer.Pathology oncology research : POR · 2018Article
- Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.British journal of cancer · 2018Article
- Significance of intratissue estrogen concentration coupled with estrogen receptors levels in colorectal cancer prognosis.Oncotarget · 2017Article
- Reproductive factors, hormones and colorectal cancer-still unresolved.British journal of cancer · 2017Article
- Mismatch Repair Protein hMLH1, but not hMSH2, Enhances Estrogen-Induced Apoptosis of Colon Cancer Cells.Journal of Cancer · 2017Article
- Estrogen receptors and their implications in colorectal carcinogenesis.Frontiers in oncology · 2015Review
- Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women.Cancer research · 2013Article
- Expression of oestrogen receptor β and prognosis of colorectal cancer.British journal of cancer · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study was designed to investigate the clinicopathological correlations, relationship to apoptotic index, and prognostic significance of estrogen receptor beta expression in colorectal carcinoma.
methodsThe study was carried out on 40 patients with newly diagnosed colorectal cancer. The patients' data were collected prospectively and the 2 years overall survival was the endpoint. Estrogen receptor beta expression was assessed by immunohistochemistry. Apoptotic body index was calculated by counting apoptotic cells using the modified TUNEL assay.
resultsEstrogen receptor beta positivity was detected in 65% of colorectal cancer cases, while estrogen receptor alpha positivity was found in only 7% of cases. The rate of estrogen receptor beta immunoreactivity was significantly higher in low-grade colorectal tumors. The median apoptotic index in estrogen receptor beta positive cases was significantly higher than in estrogen receptor beta negative cases (6% versus 3%; p = 0.01). The median overall survival was higher in estrogen receptor beta positive cases (22 versus 18 months); however, the difference was not statistically significant.
conclusionsThe study results reinforce the importance of the estrogen receptor beta rather than the estrogen receptor alpha in colorectal cancer. Lack of estrogen receptor beta expression is associated with loss of differentiation and decreased apoptosis. Future studies should include validation of estrogen receptor beta as a prognostic marker and exploration of its role as a target in the management of colorectal cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.