ArticleJournal of neuro-oncology2011
Analysis of cytogenetic aberrations in sporadic vestibular schwannoma by comparative genomic hybridization.
Article in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Contemporary Molecular Biology of Sporadic Vestibular Schwannomas: A Systematic Review and Clinical Implications.The journal of international advanced otology · 2018Pooled it
- Gamma Knife Radiosurgery does not alter the copy number aberration profile in sporadic vestibular schwannoma.Journal of neuro-oncology · 2020Article
- Whole Genome Sequencing Identifies Key Genes in Spinal Schwannoma.Frontiers in genetics · 2020Article
- Malignant triton tumor of trigeminal nerve-case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Evidence of polyclonality in neurofibromatosis type 2-associated multilobulated vestibular schwannomas.Neuro-oncology · 2015Article
- DNA copy gains of tumor-related genes in vestibular schwannoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Merlin, the NF2 gene product.Pathology oncology research : POR · 2013Review
- Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.Brain : a journal of neurology · 2013Article
- Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients.Croatian medical journal · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vestibular schwannomas (VS) are benign tumors of the nervous system that are usually sporadic but also occur in the inherited disorder neurofibromatosis type 2 (NF2). The NF2 gene is a tumor suppressor gene located on chromosome 22. Loss of the NF2 protein product, Merlin, is universal in both sporadic and NF2-related schwannomas and the loss or mutation of the gene is the only established causative event underlying schwannoma formation. Comparative genomic hybridization (CGH) was used to screen 20 sporadic VS to identify additional chromosomal regions that may harbor genes involved in VS-tumorigenesis. The most common change were losses on chromosome 22q. Additionally, losses were observed on chromosome 9p indicating a possible participation of the CDKN2A tumor suppressor gene in the genesis of VS. Gains were observed on 17q, 19p and 19q, which have been reported before in malignant peripheral nerve sheath tumors that are associated with neurofibromatosis type 1. Importantly, high level amplifications have been observed on 16p and 16q as well as on 9q, suggesting the possible involvement of several oncogenes in the tumorigenesis of VS. Our data suggest the involvement of various oncogenes and tumor suppressor genes might play a role in the genesis of the vestibular schwannomas apart from the inactivation of the NF2 gene.
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Registered trials
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