ArticleThe Journal of membrane biology2010
Effect of membrane structure on the action of polyenes: I. Nystatin action in cholesterol- and ergosterol-containing membranes.
Article in The Journal of membrane biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Passage of the Channel-Forming Agent Nystatin Through Ergosterol-Containing Lipid Membranes.The Journal of membrane biology · 2025Article
- Efficacy and Molecular Mechanisms of Nystatin AgainstFoods (Basel, Switzerland) · 2024Article
- Antibiotic Loaded Phytosomes as a Way to Develop Innovative Lipid Formulations of Polyene Macrolides.Pharmaceutics · 2024Article
- Antifungal activity and mechanism of oxanthromicin against Verticillium dahliae.Archives of microbiology · 2024Article
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- Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications.Membranes · 2022Review
- Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy.International journal of pediatric endocrinology · 2020Article
- Polymeric films as a promising carrier for bioadhesive drug delivery: Development, characterization and optimization.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017Article
- Cross-talk between Dopachrome Tautomerase and Caveolin-1 Is Melanoma Cell Phenotype-specific and Potentially Involved in Tumor Progression.The Journal of biological chemistry · 2016Article
- Evaluation of nystatin isolated from Streptomyces griseus SDX-4 against the ciliate, Ichthyophthirius multifiliis.Parasitology research · 2015Article
- Investigation of channel-forming activity of polyene macrolide antibiotics in planar lipid bilayers in the presence of dipole modifiers.Acta naturae · 2014Article
- Cell penetrating peptides and cationic antibacterial peptides: two sides of the same coin.The Journal of biological chemistry · 2014Article
- Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A detailed and thorough characterization of nystatin-induced permeability on lipid bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)-containing ergosterol or cholesterol is presented. The results show that the same collection of transmembrane pores appears in membranes containing either sterol. The concentration range for the appearance of these pores is sterol-dependent. Another mechanism of action, membrane disruption, is also observed in ergosterol-POPC membranes. The greater potency of nystatin present in ergosterol-containing membranes cannot be explained simply by the longer opening times of its pores, as has been suggested; it is also due to an increased number of events in these membranes. The present results and those of a companion paper lead us to propose that membrane structure is the determining factor for drug selectivity in membranes with different sterols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.