ArticlePediatric nephrology (Berlin, Germany)2010
Vitamin D insufficiency and effect of cholecalciferol in children with chronic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Changes in bone biomarkers in response to different dosing regimens of cholecalciferol supplementation in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Trial
- Randomized trial of two maintenance doses of vitamin D in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022Trial
- Is high-dose cholecalciferol justified in children with chronic kidney disease who failed low-dose maintenance therapy?Pediatric nephrology (Berlin, Germany) · 2013Trial
- The role of nutritional vitamin D in chronic kidney disease-mineral and bone disorder in children and adults with chronic kidney disease, on dialysis, and after kidney transplantation-a European consensus statement.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- The clinical relevance of native vitamin D in pediatric kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Review
- Vitamin D supplementation in children and young adults with persistent proteinuria secondary to glomerular disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Article
- Native vs. active vitamin D in children with chronic kidney disease: a cross-over study.Pediatric nephrology (Berlin, Germany) · 2021Article
- The Use of Vitamin D Metabolites and Analogues in the Treatment of Chronic Kidney Disease.Endocrinology and metabolism clinics of North America · 2017Review
- Clinical practice recommendations for native vitamin D therapy in children with chronic kidney disease Stages 2-5 and on dialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2016Article
- Disordered FGF23 and mineral metabolism in children with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2014Observational
- Vitamin D bioavailability and catabolism in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Article
- Phosphate binders, vitamin D and calcimimetics in the management of chronic kidney disease-mineral bone disorders (CKD-MBD) in children.Pediatric nephrology (Berlin, Germany) · 2013Review
- Vitamin D: effects on childhood health and disease.Nature reviews. Endocrinology · 2013Review
- Vitamin D status of children receiving chronic dialysis.Pediatric nephrology (Berlin, Germany) · 2012Article
- Vitamin D in chronic kidney disease.Indian journal of pediatrics · 2012Review
- Vitamin D supplementation in pre-dialysis chronic kidney disease: A systematic review.Dermato-endocrinology · 2012Article
- Vitamin D deficiency is common in children and adolescents with chronic kidney disease.Kidney international · 2012Article
- Mineral and bone disorders in children with chronic kidney disease.Nature reviews. Nephrology · 2011Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D insufficiency is common in patients with chronic kidney disease (CKD) and may contribute to mineral bone disease. In a prospective interventional study, we estimated the prevalence of vitamin D insufficiency (serum 25-hydroxyvitamin D3 [25OHD] < 30 ng/ml), and examined the effect of high-dose (600,000 IU) cholecalciferol supplementation after 6 weeks on serum 25OHD and parathyroid hormone (PTH) levels in children with CKD stages 2-4. Forty-two children (86% boys) with a mean age of 7.7 ± 3.8 (range 2--5) years were studied. Thirty-seven children (82.1%) had vitamin D insufficiency; 18 (42.8%) had 25OHD < 16 ng/ml. The median 25OHD increased significantly from 16.7 (95% CI 11.3, 19.8) to 46.2 (34.5, 44.6) ng/ml in patients with vitamin D insufficiency (P <0.001). The median PTH decreased significantly from 51.3 (95% CI 46.7, 71.5) to 37.1 (29.0, 54.6) pg/ml (P = 0.003). Nineteen patients (47.5%) had >30% reduction in the PTH after supplementation. Serum calcium, phosphorus, and estimated GFR did not change significantly. We conclude that vitamin D insufficiency is highly prevalent in children with CKD stages 2-4. High-dose cholecalciferol is safe and effective in correcting vitamin D insufficiency and results in a significant reduction in PTH levels in vitamin D-insufficient children.
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Registered trials
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