ArticlePharmaceutical research2010
Delivery of water-soluble drugs using acoustically triggered perfluorocarbon double emulsions.
Article in Pharmaceutical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 152 citations in OpenAlex.
- Phase-change perfluorocarbon nanodroplets enable spatiotemporal control of ultrasound and photoacoustic imaging and therapy.Biomedical engineering letters · 2026Review
- Real-time drug release monitoring from acoustically responsive scaffolds.Ultrasonics sonochemistry · 2026Article
- Controlled Antibiotic Release From Emulsion-Loaded Alginate and Fibrin Hydrogels Using Ultrasound.Journal of biomedical materials research. Part A · 2026Article
- Double-Emulsion Perfluorocarbon Nanodroplets for Ultrasound and Photoacoustic Image-Guided Drug Delivery and Release.ACS nano · 2025Article
- Janus acoustically responsive scaffolds for sequential drug release with phase-programmed steady and pulsatile kinetics.Journal of colloid and interface science · 2025Article
- Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation.Nature nanotechnology · 2025Article
- Real-Time Optical and Acoustic Characterization of Phase-Shift Droplets for Drug-Delivery Applications.ACS applied materials & interfaces · 2025Article
- Optical and Acoustic Characterization of Phase-Shift Droplets with Varying Shell Compositions.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Acoustically responsive scaffolds: Unraveling release kinetics and mechanisms for sustained, steady drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Article
- Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions.Zeitschrift fur medizinische Physik · 2023Review
- Shortwave Infrared Fluorofluorophores for Multicolor In Vivo Imaging.Angewandte Chemie (International ed. in English) · 2023Article
- Activation of Phase Change Contrast Agents Using Ionizing Radiation.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022Article
- Ultrasound-triggered oxygen-loaded nanodroplets enhance and monitor cerebral damage from sonodynamic therapy.Nanotheranostics · 2022Article
- Optical sensor arrays designed for guided manufacture of perfluorocarbon nanoemulsions with a non-synthetic stabilizer.Acta biomaterialia · 2021Article
- Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds.Acta biomaterialia · 2021Article
- Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release.Ultrasonics sonochemistry · 2021Article
- Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds.Ultrasonics sonochemistry · 2020Article
- Combined gas embolization and chemotherapy can result in complete tumor regression in a murine hepatocellular carcinoma model.APL bioengineering · 2020Article
- A fluorous biphase drug delivery system triggered by low frequency ultrasound: controlled release from perfluorous discoidal porous silicon particles.Nanoscale advances · 2020Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeUltrasound can be used to release a therapeutic payload encapsulated within a perfluorocarbon (PFC) emulsion via acoustic droplet vaporization (ADV), a process whereby the PFC phase is vaporized and the agent is released. ADV-generated microbubbles have been previously used to selectively occlude blood vessels in vivo. The coupling of ADV-generated drug delivery and occlusion has therapeutically synergistic potentials.
methodsMicron-sized, water-in-PFC-in-water (W(1)/PFC/W(2)) emulsions were prepared in a two-step process using perfluoropentane (PFP) or perfluorohexane (PFH) as the PFC phase. Fluorescein or thrombin was contained in the W(1) phase.
resultsDouble emulsions containing fluorescein in the W(1) phase displayed a 5.7±1.4-fold and 8.2±1.3-fold increase in fluorescein mass flux, as measured using a Franz diffusion cell, after ADV for the PFP and PFH emulsions, respectively. Thrombin was stably retained in four out of five double emulsions. For three out of five formulations tested, the clotting time of whole blood decreased, in a statistically significant manner (p < 0.01), when incubated with thrombin-loaded emulsions exposed to ultrasound compared to emulsions not exposed to ultrasound.
conclusionsADV can be used to spatially and temporally control the delivery of water-soluble compounds formulated in PFC double emulsions. Thrombin release could extend the duration of ADV-generated, microbubble occlusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.