ReviewJournal of neuro-oncology2011
Rosette-forming glioneuronal tumor: a pineal region case with IDH1 and IDH2 mutation analyses and literature review of 43 cases.
Review in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Pooled it
- The Clinical and Molecular Landscape of Rosette-Forming Glioneuronal Tumors.Biomedicines · 2024Review
- Paediatric low-grade glioma: the role of classical pathology in integrated diagnostic practice.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Diffusely invasive supratentorial rosette-forming glioneuronal tumor: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Recurrent anaplastic transformation of a Vermian region rosette forming glioneuronal tumour - A rare entity. Case report and review of literature.International journal of surgery case reports · 2023Article
- Large pineal parenchymal tumor of intermediate differentiation causing compression with resultant obstructive hydrocephalus: a case report.Annals of medicine and surgery (2012) · 2023Article
- Article
- Molecular analyses of rosette-forming glioneuronal tumor of the midbrain tegmentum: A report of two cases and a review of the FGFR1 status in unusual tumor locations.Surgical neurology international · 2022Article
- Rosette-forming glioneuronal tumor of the fourth ventricle; A case report and review of the literature.Clinical case reports · 2021Article
- Pineal region tumors: pathophysiological mechanisms of presenting symptoms.American journal of translational research · 2021Review
- Supratentorial intraventricular rosette-forming glioneuronal tumors - Case report and review of treatment paradigms.Surgical neurology international · 2020Article
- Iodine promotes thyroid cancer development via SPANXA1 through the PI3K/AKT signalling pathway.Oncology letters · 2019Article
- Malignant Transformation of a Rosette-Forming Glioneuronal Tumor with IDH1 Mutation: A Case Report and Literature Review.World neurosurgery: X · 2019Article
- Comprehensive genetic characterization of rosette-forming glioneuronal tumors: independent component analysis by tissue microdissection.Brain pathology (Zurich, Switzerland) · 2018Article
- Histopathological, molecular, clinical and radiological characterization of rosette-forming glioneuronal tumor in the central nervous system.Oncotarget · 2017Article
- Remote intracranial recurrence ofOncotarget · 2017Article
- Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters.Journal of neuro-oncology · 2017Article
- Integrated tumor and germline whole-exome sequencing identifies mutations in MAPK and PI3K pathway genes in an adolescent with rosette-forming glioneuronal tumor of the fourth ventricle.Cold Spring Harbor molecular case studies · 2016Article
- Rosette-forming glioneuronal tumor outside the fourth ventricle: a case-based update.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a mixed glio-neuronal neoplasm recently codified by the World Health Organization WHO Classification of Central Nervous System (CNS) Tumors (2007). To date, 43 cases have been described in the literature; most occurring in the fourth ventricle region. We report the fourth case involving the pineal region in a 16-year-old female with signs of increased intracranial pressure (ICP). A stereotactic biopsy of the mass was followed by a debulking procedure. Both specimens revealed classic RGNT histology. The patient had stable scans 7 months post-resection. The clinical, radiological and histopathologic features of the previously described 43 cases are reviewed along with our illustrative case. Mean age of patients was 30 ± 12.8 years with 1.9:1 female to male ratio. The most common presenting signs related to increased ICP and posterior fossa involvement, including: headache (62.8%), ataxia (39.5%) and vomiting and vertigo (both 16.3%). This tumor usually presents with cystic changes (54.5%) with focal enhancement (60.9%) and hydrocephalus (43.2%). Microcalcifications and satellite lesions were common radiographic observations. All reported cases had the classic biphasic pattern. Rosenthal fibers and eosinophilic granular bodies are each present in approximately two thirds of cases. Ki-67 labeling index is consistently low (mean (%): 1.8 ± 0.75 SD). The isocitrate dehydrogenase 1 or 2 mutation found in low grade diffuse gliomas is not identified in this RGNT case. Reported outcome is nearly uniformly excellent after complete or subtotal resection. A solitary report of recurrence after 10 years and the limited experience with this entity suggest that long term follow up is advisable.
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