ArticleThe Journal of membrane biology2010
Effect of membrane structure on the action of polyenes II: nystatin activity along the phase diagram of ergosterol- and cholesterol-containing POPC membranes.
Article in The Journal of membrane biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Passage of the Channel-Forming Agent Nystatin Through Ergosterol-Containing Lipid Membranes.The Journal of membrane biology · 2025Article
- Antibiotic Loaded Phytosomes as a Way to Develop Innovative Lipid Formulations of Polyene Macrolides.Pharmaceutics · 2024Article
- Article
- Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications.Membranes · 2022Review
- Investigation of channel-forming activity of polyene macrolide antibiotics in planar lipid bilayers in the presence of dipole modifiers.Acta naturae · 2014Article
- Cell penetrating peptides and cationic antibacterial peptides: two sides of the same coin.The Journal of biological chemistry · 2014Article
- Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
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Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pores formed by the polyene antibiotic nystatin were studied in solvent-free lipid membranes. The membranes were formed by the tip-dip technique using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) with different mol fractions (0-50%) of cholesterol or ergosterol. The effects of the mol fraction of sterol and of temperature variation (15-35°C) on the activity of the pores, their unitary conductances, lifetimes and time average conductances were studied. The results were used to analyze the behavior of nystatin channels along the phase diagrams previously reported for these lipid mixtures and to propose that membrane structure is the determinant factor for the known ergosterol/cholesterol selectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.