ArticleActa pharmacologica Sinica2010
Genetic analysis of six SNPs in candidate genes associated with high cross-race risk of development of thoracic aortic aneurysms and dissections in Chinese Han population.
Article in Acta pharmacologica Sinica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- X-linked genetic associations in sporadic thoracic aortic dissection.American journal of medical genetics. Part A · 2024Pooled it
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- DNA methylation alternation in Stanford- A acute aortic dissection.BMC cardiovascular disorders · 2022Article
- Genetic Variation inJournal of cardiovascular development and disease · 2022Article
- Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions.Cardiovascular drugs and therapy · 2020Article
- Prevalence and clinical characteristics of pseudohypertension in elderly patients prepared for coronary artery angiography.Medicine · 2017Article
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- Color M-mode echocardiography-derived propagation velocity of descending aorta decreases with aging.Therapeutics and clinical risk management · 2017Article
- Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction.Therapeutics and clinical risk management · 2017Article
- Sex differences of in-hospital outcome and long-term mortality in patients with Takotsubo cardiomyopathy.Therapeutics and clinical risk management · 2017Article
- MMP-2 gene polymorphisms are associated with type A aortic dissection and aortic diameters in patients.Medicine · 2016Observational
- Higher prevalence of elevated LDL-C than non-HDL-C and low statin treatment rate in elderly community-dwelling Chinese with high cardiovascular risk.Scientific reports · 2016Article
- Article
- Association of MMP-2 gene haplotypes with thoracic aortic dissection in chinese han population.BMC cardiovascular disorders · 2016Article
- Association of the polymorphisms of MMP-9 and TIMP-3 genes with thoracic aortic dissection in Chinese Han population.Acta pharmacologica Sinica · 2014Article
- Impact of thrombospondin-2 gene variations on the risk of thoracic aortic dissection in a Chinese Han population.International journal of clinical and experimental medicine · 2014Article
- Angiotensin-converting enzyme I/D polymorphism and the risk of thoracic aortic dissection in Chinese Han population.Molecular biology reports · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimGenetic susceptibility is an important risk factor for aortic aneurysm and dissection. Recent case-control association studies have identified six single nucleotide polymorphisms (SNPs) associated with abdominal aortic aneurysm (AAA) in a Caucasian population. We aimed to determine whether these loci confer susceptibility to thoracic aortic dissection (TAD) in a Chinese Han population and thus to establish cross-race susceptibility to TAD.
methodsThis study analyzed blood DNA isolated from 206 TAD patients and 180 controls from the ethnic Chinese Han population. Six SNPs - rs819146, rs8003379, rs2853523, rs326118, rs3788205, and rs10757278 - were genotyped using high-throughput matrix-assisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry.
resultsThe A allele frequency for the SNP on 9p21, tagged as rs10757278, was higher in male TAD patients than in male controls (P=0.017). Moreover, with adjustment for traditional cardiovascular risk factors (sex, age, hypertension, dyslipidemia, diabetes, and smoking), the rs10757278 [odds ratio (OR) 0.63, 95% confidence interval (CI) 0.43 to 0.93] polymorphism was found to be an independent susceptibility factor for TAD in men.
conclusionOur results suggest that a sequence variant on 9p21 is an important susceptibility locus that confers high cross-race risk for development of TAD in Chinese Han population.
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