ArticleGenetics2010
Natural variation, functional pleiotropy and transcriptional contexts of odorant binding protein genes in Drosophila melanogaster.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 72 citations in OpenAlex.
- Adaptive Evolution of Odorant-Binding and Chemosensory Protein Gene Families in GenusBiomolecules · 2026Article
- The impact of exercise on protein levels in Drosophila melanogaster.Biology open · 2026Article
- Genome-Wide Identification and Expression Analyses of Odorant-Binding Proteins in HoverflyInternational journal of molecular sciences · 2025Article
- Chromosome-level genome assembly of the synanthropic fly Chrysomya megacephala: insights into oviposition location.BMC genomics · 2025Article
- DGRPool, a web tool leveraging harmonizedeLife · 2024Article
- Article
- Genetic, Environmental, and Stochastic Components of Lifespan Variability: TheInternational journal of molecular sciences · 2024Review
- Odorant-Binding and Chemosensory Proteins in Fig Wasps: Evolutionary Insights From Comparative Studies.Journal of molecular evolution · 2024Article
- The genetic architecture of behavioral canalization.Trends in genetics : TIG · 2023Review
- Pleiotropic fitness effects of a Drosophila odorant-binding protein.G3 (Bethesda, Md.) · 2023Article
- Mutually Exclusive Expression of Closely Related Odorant-Binding Proteins 9A and 9B in the Antenna of the Red Flour BeetleBiomolecules · 2021Article
- Sex, mating and repeatability ofRoyal Society open science · 2021Article
- Functional Diversification, Redundancy, and Epistasis among Paralogs of the Drosophila melanogaster Obp50a-d Gene Cluster.Molecular biology and evolution · 2021Article
- Expansions of chemosensory gene orthologs among selected tsetse fly species and their expressions in Glossina morsitans morsitans tsetse fly.PLoS neglected tropical diseases · 2020Article
- TheG3 (Bethesda, Md.) · 2020Article
- Review
- Evolution of Epistatic Networks and the Genetic Basis of Innate Behaviors.Trends in genetics : TIG · 2020Review
- Article
- The road less traveled: from genotype to phenotype in flies and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Brain transcriptome changes in the aging Drosophila melanogaster accompany olfactory memory performance deficits.PloS one · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
How functional diversification affects the organization of the transcriptome is a central question in systems genetics. To explore this issue, we sequenced all six Odorant binding protein (Obp) genes located on the X chromosome, four of which occur as a cluster, in 219 inbred wild-derived lines of Drosophila melanogaster and tested for associations between genetic and phenotypic variation at the organismal and transcriptional level. We observed polymorphisms in Obp8a, Obp19a, Obp19b, and Obp19c associated with variation in olfactory responses and polymorphisms in Obp19d associated with variation in life span. We inferred the transcriptional context, or "niche," of each gene by identifying expression polymorphisms where genetic variation in these Obp genes was associated with variation in expression of transcripts genetically correlated to each Obp gene. All six Obp genes occupied a distinct transcriptional niche. Gene ontology enrichment analysis revealed associations of different Obp transcriptional niches with olfactory behavior, synaptic transmission, detection of signals regulating tissue development and apoptosis, postmating behavior and oviposition, and nutrient sensing. Our results show that diversification of the Obp family has organized distinct transcriptional niches that reflect their acquisition of additional functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.