ArticleThe Plant cell2010
Hydrogen peroxide-mediated activation of MAP kinase 6 modulates nitric oxide biosynthesis and signal transduction in Arabidopsis.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
110 citing papers in PubMed, 304 citations in OpenAlex.
- CIPK11 Regulates Plant Adaptation to Nitrate Availability in Arabidopsis.Plants (Basel, Switzerland) · 2026Article
- Overexpression ofInternational journal of molecular sciences · 2026Article
- Functional divergence and symbiotic significance of nitrate reductase isoforms in Medicago truncatula.Plant physiology · 2026Article
- Nitrate reductase-mediated production of nitric oxide enhances cold tolerance in rice seedlings.Scientific reports · 2026Article
- Methylome and Transcriptome Analysis Reveals Differences in Callus Development and Plantlet Regeneration Capacity Between TwoPlants (Basel, Switzerland) · 2026Article
- Plant Growth-Promoting Microorganisms Mediate Plant Metabolic Reprogramming to Manage the Rhizospheric Microbiome.Microorganisms · 2026Review
- 5-Aminolevulinic acid improves strawberry salt tolerance through a NO-HJournal of advanced research · 2025Article
- Redox-Epigenetic Crosstalk in Plant Stress Responses: The Roles of Reactive Oxygen and Nitrogen Species in Modulating Chromatin Dynamics.International journal of molecular sciences · 2025Review
- Insight into the Functional Role of SiMPK6 in Stress Response and Photosynthetic Efficiency inPlants (Basel, Switzerland) · 2025Article
- Short-Term Fertilization with the Nitrogen-Fixing Bacterium (NFB)Microorganisms · 2025Article
- Nitrate activates an MKK3-dependent MAPK module via NLP transcription factors in Arabidopsis.The Plant journal : for cell and molecular biology · 2025Article
- Transcriptome Analysis of Potato Leaves under Oxidative Stress.International journal of molecular sciences · 2024Article
- Bioinformatic Identification and Expression Analyses of the MAPK-MAP4K Gene Family Reveal a Putative Functional MAP4K10-MAP3K7/8-MAP2K1/11-MAPK3/6 Cascade in Wheat (Plants (Basel, Switzerland) · 2024Article
- Characterization ofPlants (Basel, Switzerland) · 2024Article
- Functional interaction of melatonin with gasotransmitters and ROS in plant adaptation to abiotic stresses.Frontiers in plant science · 2024Review
- Gallic acid regulates primary root elongation via modulating auxin transport and signal transduction.Frontiers in plant science · 2024Article
- Genome-Wide Identification and Analysis of the WNK Kinase Gene Family in Upland Cotton.Plants (Basel, Switzerland) · 2023Article
- HPlant, cell & environment · 2023Review
- Nitrate reductase enzymes in algaFrontiers in microbiology · 2023Article
- SnRK2.10 kinase differentially modulates expression of hub WRKY transcription factors genes under salinity and oxidative stress inFrontiers in plant science · 2023Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a bioactive molecule that functions in numerous physiological and developmental processes in plants, including lateral root development. In this study, we used biochemical and genetic approaches to analyze the function of Arabidopsis thaliana mitogen-activated protein kinase 6 (MPK6) in the regulation of NO synthesis in response to hydrogen peroxide (H₂O₂) during lateral root development. In both mpk6 mutants studied, H₂O₂-induced NO synthesis and nitrate reductase (NR) activity were decreased dramatically. Furthermore, one NR isoform, NIA2, was required for the MPK6-mediated production of NO induced by H₂O₂. Notably, NIA2 interacted physically with MPK6 in vitro and in vivo and also served as a substrate of MPK6. Phosphorylation of NIA2 by MPK6 led to an increase in NR activity, and Ser-627 was identified as the putative phosphorylation site on NIA2. Phenotypical analysis revealed that mpk6-2 and mpk6-3 seedlings produce more and longer lateral roots than wild-type plants did after application of the NO donor sodium nitroprusside or H₂O₂. These data support strongly a function of MPK6 in modulating NO production and signal transduction in response to H₂O₂ during Arabidopsis root development.
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