ArticleJournal of bacteriology2010
Stability and instability in the lysogenic state of phage lambda.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 56 citations in OpenAlex.
- Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026Review
- Extensive library ofMicrobiology spectrum · 2026Article
- Cyclo-stationary distributions of mRNA and Protein counts for random cell division times.bioRxiv : the preprint server for biology · 2025Article
- Eco-evolutionary dynamics of temperate phages in periodic environments.Virus evolution · 2025Article
- Fine-tuned spatiotemporal dynamics of DNA replication during phage lambda infection.Journal of virology · 2024Article
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- CRISPRpi: Inducing and Curing Prophage Using the CRISPR Interference.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Characterization of Temperate LPS-Binding Bordetella avium Phages That Lack Superinfection Immunity.Microbiology spectrum · 2023Article
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- Disarm The Bacteria: What Temperate Phages Can Do.Current issues in molecular biology · 2023Review
- RecT Affects Prophage Lifestyle and Host Core Cellular Processes in Pseudomonas aeruginosa.Applied and environmental microbiology · 2022Article
- The Life Cycle Transitions of Temperate Phages: Regulating Factors and Potential Ecological Implications.Viruses · 2022Review
- The microbiome-product colibactin hits unique cellular targets mediating host-microbe interaction.Frontiers in pharmacology · 2022Review
- Bacteriophage λ RexA and RexB functions assist the transition from lysogeny to lytic growth.Molecular microbiology · 2021Article
- Article
- Optimality of the spontaneous prophage induction rate.Journal of theoretical biology · 2019Article
- The Prophages ofJournal of bacteriology · 2019Article
- Cell fate potentials and switching kinetics uncovered in a classic bistable genetic switch.Nature communications · 2018Article
- Regeneration of Escherichia coli from Minicells through Lateral Gene Transfer.Journal of bacteriology · 2018Article
- Characterization of the Prophage Repertoire of AfricanFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Complex gene regulatory circuits exhibit emergent properties that are difficult to predict from the behavior of the components. One such property is the stability of regulatory states. Here we analyze the stability of the lysogenic state of phage λ. In this state, the virus maintains a stable association with the host, and the lytic functions of the virus are repressed by the viral CI repressor. This state readily switches to the lytic pathway when the host SOS system is induced. A low level of SOS-dependent switching occurs without an overt stimulus. We found that the intrinsic rate of switching to the lytic pathway, measured in a host lacking the SOS response, was almost undetectably low, probably less than 10(-8)/generation. We surmise that this low rate has not been selected directly during evolution but results from optimizing the rate of switching in a wild-type host over the natural range of SOS-inducing conditions. We also analyzed a mutant, λprm240, in which the promoter controlling CI expression was weakened, rendering lysogens unstable. Strikingly, the intrinsic stability of λprm240 lysogens depended markedly on the growth conditions; lysogens grown in minimal medium were nearly stable but switched at high rates when grown in rich medium. These effects on stability likely reflect corresponding effects on the strength of the prm240 promoter, measured in an uncoupled assay system. Several derivatives of λprm240 with altered stabilities were characterized. This mutant and its derivatives afford a model system for further analysis of stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.