ArticleThe Journal of biological chemistry2010
PfSRPK1, a novel splicing-related kinase from Plasmodium falciparum.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- DivergentLife science alliance · 2025Article
- Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle.International journal of molecular sciences · 2024Review
- Article
- Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens.BMC genomics · 2022Article
- Transcriptomic complexity of the human malaria parasite Plasmodium falciparum revealed by long-read sequencing.PloS one · 2022Article
- An Update on Development of Small-Molecule Plasmodial Kinase Inhibitors.Molecules (Basel, Switzerland) · 2020Review
- Review
- Culture adaptation of malaria parasites selects for convergent loss-of-function mutants.Scientific reports · 2017Article
- Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.Current drug discovery technologies · 2016Review
- A bioinformatic survey of RNA-binding proteins in Plasmodium.BMC genomics · 2015Article
- A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii.Nucleic acids research · 2015Article
- Transcript maturation in apicomplexan parasites.Current opinion in microbiology · 2014Review
- Article
- Organization of Plasmodium falciparum spliceosomal core complex and role of arginine methylation in its assembly.Malaria journal · 2013Article
- Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development.Journal of proteome research · 2013Article
- Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito.BMC genomics · 2013Article
- A novel subnetwork alignment approach predicts new components of the cell cycle regulatory apparatus in Plasmodium falciparum.BMC bioinformatics · 2013Article
- A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes.Nucleic acids research · 2012Article
- A unique Kelch domain phosphatase in Plasmodium regulates ookinete morphology, motility and invasion.PloS one · 2012Article
- Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa.BMC evolutionary biology · 2011Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though it is increasingly evident that post-transcriptional events like mRNA processing and splicing may regulate gene expression and proteome diversity of malaria parasite Plasmodium, molecular mechanisms that regulate events like mRNA splicing in malaria parasite are poorly understood. Protein kinases control a wide variety of cellular events in almost all eukaryotes, including modulation of mRNA splicing, transport, and stability. We have identified a novel splicing-related protein kinase from Plasmodium falciparum, PfSRPK1. PfSRPK1 when incubated with parasite nuclear extracts inhibited RNA splicing, suggesting that it may control mRNA splicing in the parasite. PfSR1, a putative splicing factor from P. falciparum, was identified as a substrate of PfSRPK1. PfSR1 interacts with RNA and PfSRPK1 modulates its RNA binding. Early in the parasite development, PfSRPK1 and PfSR1 are present in the nucleus. These studies provide useful insights into the function of two potentially key components of P. falciparum mRNA splicing machinery.
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