ReviewCurrent opinion in structural biology2010
Origin DNA melting and unwinding in DNA replication.
Review in Current opinion in structural biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.Briefings in bioinformatics · 2026Article
- Weak tension accelerates hybridization and dehybridization of short oligonucleotides.Nucleic acids research · 2023Article
- Controllable DNA hybridization by host-guest complexation-mediated ligand invasion.Nature communications · 2022Article
- Article
- Arabidopsis DNA Replication Initiates in Intergenic, AT-Rich Open Chromatin.Plant physiology · 2020Article
- The ring-shaped hexameric helicases that function at DNA replication forks.Nature structural & molecular biology · 2018Review
- DNA substrate recognition and processing by the full-length human UPF1 helicase.Nucleic acids research · 2017Article
- Study of SV40 large T antigen nucleotide specificity for DNA unwinding.Virology journal · 2017Article
- Review
- Bacteriophage T5 gene D10 encodes a branch-migration protein.Scientific reports · 2016Article
- Novel insight into the composition of human single-stranded DNA-binding protein 1 (hSSB1)-containing protein complexes.BMC molecular biology · 2016Article
- Article
- DNA replication: Strand separation unravelled.Nature · 2015Article
- Insights into the Initiation of Eukaryotic DNA Replication.Nucleus (Austin, Tex.) · 2015Article
- Loading strategies of ring-shaped nucleic acid translocases and helicases.Current opinion in structural biology · 2014Review
- Dynamic look at DNA unwinding by a replicative helicase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Principles and concepts of DNA replication in bacteria, archaea, and eukarya.Cold Spring Harbor perspectives in biology · 2013Review
- Loading mechanisms of ring helicases at replication origins.Molecular microbiology · 2012Review
- Quality control in the initiation of eukaryotic DNA replication.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin.Journal of molecular biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Genomic DNA replication is a necessary step in the life cycles of all organisms. To initiate DNA replication, the double-stranded DNA (dsDNA) at the origin of replication must be separated or melted; this melted region is propagated and a mature replication fork is formed. To accomplish origin recognition, initial DNA melting, and the eventual formation of a replication fork, coordinated activity of initiators, helicases, and other cellular factors are required. In this review, we focus on recent advances in the structural and biochemical studies of the initiators and the replicative helicases in multiple replication systems, with emphasis on the systems in archaeal and eukaryotic cells. These studies have yielded insights into the plausible mechanisms of the early stages of DNA replication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.