ArticleMolecular and cellular neurosciences2011
A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons.
Article in Molecular and cellular neurosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration.Frontiers in neuroscience · 2022Review
- Targeting chondroitinase ABC to axons enhances the ability of chondroitinase to promote neurite outgrowth and sprouting.PloS one · 2020Article
- miR-181d-5p promotes neurite outgrowth in PC12 Cells via PI3K/Akt pathway.CNS neuroscience & therapeutics · 2017Article
- Exploring Optic Nerve Axon Regeneration.Current neuropharmacology · 2017Review
- Sialic Acid Is Required for Neuronal Inhibition by Soluble MAG but not for Membrane Bound MAG.Frontiers in molecular neuroscience · 2016Article
- Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders.Journal of neurochemistry · 2015Article
- PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Extrinsic and intrinsic regulation of axon regeneration at a crossroads.Frontiers in molecular neuroscience · 2015Article
- Loss of GABAergic cortical neurons underlies the neuropathology of Lafora disease.Molecular brain · 2014Article
- Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders.Frontiers in molecular neuroscience · 2014Review
- Differential role of PTEN phosphatase in chemotactic growth cone guidance.The Journal of biological chemistry · 2013Article
- PTEN modulators: a patent review.Expert opinion on therapeutic patents · 2013Review
- Atypical protein kinase C and Par3 are required for proteoglycan-induced axon growth inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Axonal regeneration in the central nervous system is prevented, in part, by inhibitory proteins expressed by myelin, including myelin-associated glycoprotein (MAG). Although injury to the corticospinal tract can result in permanent disability, little is known regarding the mechanisms by which MAG affects cortical neurons. Here, we demonstrate that cortical neurons plated on MAG expressing CHO cells, exhibit a striking reduction in process outgrowth. Interestingly, none of the receptors previously implicated in MAG signaling, including the p75 neurotrophin receptor or gangliosides, contributed significantly to MAG-mediated inhibition. However, blocking the small GTPase Rho or its downstream effector kinase, ROCK, partially reversed the effects of MAG on the neurons. In addition, we identified the lipid phosphatase PTEN as a mediator of MAG's inhibitory effects on neurite outgrowth. Knockdown or gene deletion of PTEN or overexpression of activated AKT in cortical neurons resulted in significant, although partial, rescue of neurite outgrowth on MAG-CHO cells. Moreover, MAG decreased the levels of phospho-Akt, suggesting that it activates PTEN in the neurons. Taken together, these results suggest a novel pathway activated by MAG in cortical neurons involving the PTEN/PI3K/AKT axis.
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Registered trials
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