Evidence map›Paper›PMID 20869307›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2011

The theoretical model of theta burst form of repetitive transcranial magnetic stimulation.

Ying-Zu Huang, John C Rothwell, Rou-Shayn Chen, Chin-Song Lu, Wen-Li Chuang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 8 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 8 syntheses or guidelines pooled it, 301 citations in OpenAlex.

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  13. Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ying-Zu HuangDepartment of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei 10507, Taiwan. yzhuang@adm.cgmh.org.tw
John C Rothwell
Rou-Shayn Chen
Chin-Song Lu
Wen-Li Chuang
Chang Gung University · TWNational Hospital for Neurology and Neurosurgery · GB

Funding

Medical Research Council G0500258
6 · The paper itself

Abstract

objectiveTheta burst stimulation, a form of repetitive transcranial magnetic stimulation, can induce lasting changes in corticospinal excitability that are thought to involve long-term potentiation/depression (LTD/LTD)-like effects on cortical synapses. The pattern of delivery of TBS is crucial in determining the direction of change in synaptic efficiency. Previously we explained this by postulating (1) that a single burst of stimulation induces a mixture of excitatory and inhibitory effects and (2) those effects may cascade to produce long-lasting effects. Here we formalise those ideas into a simple mathematical model.

methodsThe model is based on a simplified description of the glutamatergic synapse in which post-synaptic Ca(2+) entry initiates processes leading to different amount of potentiation and depression of synaptic transmission. The final effect on the synapse results from summation of the two effects.

resultsThe model using these assumptions can fit reported data. Metaplastic effects of voluntary contraction on the response to TBS can be incorporated by changing time constants in the model.

conclusionsThe pattern-dependent after-effects and interactions with voluntary contraction can be successfully modelled by using reasonable assumptions about known cellular mechanisms of plasticity. SIGNIFICANCE: The model could provide insight into development of new plasticity induction protocols using TMS.

Indexed as

Models, NeurologicalBrainElectric StimulationEvoked Potentials, MotorHumansMotor CortexNeuronal PlasticityTranscranial Magnetic Stimulation

Identifiers

PMID20869307
PMCPMC3046904
OpenAlexW2099160703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.