Evidence map›Paper›PMID 20869073›Full record

ReviewThe Journal of surgical research2011

The immunomodulatory properties of mesenchymal stem cells: implications for surgical disease.

Brent R Weil, Mariuxi C Manukyan, Jeremy L Herrmann, Aaron M Abarbanell, Jeffrey A Poynter, Yue Wang, Daniel R Meldrum

Abstract readReview
In one paragraph

Review in The Journal of surgical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Mesenchymal stem cell therapy for cardiac repair.Current treatment options in cardiovascular medicine · 2014
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Brent R WeilDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. brweil@iupui.edu
Mariuxi C Manukyan
Jeremy L Herrmann
Aaron M Abarbanell
Jeffrey A Poynter
Yue Wang
Daniel R Meldrum
Indiana University School of Medicine

Funding

TNRF1 Signaling Resistance in Ischemic Human Female MyocardiumR01HL085595 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MELDRUM, DANIEL R · 2007 to 2010
$1.8M
Progenitor cell pretreatment against acute surgical I/RR01GM070628 · NIGMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MELDRUM, DANIEL R · 2004 to 2008
$1.5M
IL-18 Signaling in Mesenchymal Stem Cells: Function and Surgial ProtectionF32HL092718 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ABARBANELL, AARON · 2008 to 2009
$103k
Neonatal Stem Cells: Unique Traits in Paracine Signaling and CardioprotectionF32HL092719 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI HERRMANN, JEREMY · 2008 to 2009
$101k
Sex differences in TNFR2 signaling mechanisms following acute surgical ischemiaF32HL093987 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI WEIL, BRENT RICHARD · 2009 to 2009
$50k
NHLBI NIH HHS F32 HL092718NHLBI NIH HHS F32 HL092719NHLBI NIH HHS F32 HL093987NHLBI NIH HHS R01 HL085595NIGMS NIH HHS R01 GM070628
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.

Indexed as

Crohn DiseaseGraft RejectionHumansImmunomodulationMesenchymal Stem CellsMesenchymal Stem Cell TransplantationNeoplasmsSepsis

Identifiers

PMID20869073
PMCPMC3011048
OpenAlexW2062202115

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.