ArticleReproductive toxicology (Elmsford, N.Y.)2011
Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancy.
Article in Reproductive toxicology (Elmsford, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Chemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation.BMC biology · 2025Article
- Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos.Frontiers in cell and developmental biology · 2024Article
- Determinants of neural tube defects among women who gave birth in hospitals in Eastern Ethiopia: evidence from a matched case control study.BMC women's health · 2023Article
- Differential responses to maternal diabetes in embryo and visceral yolk sac.Frontiers in cell and developmental biology · 2023Article
- Aberrant lipid accumulation in the mouse visceral yolk sac resulting from maternal diabetes and obesity.Frontiers in cell and developmental biology · 2023Article
- Genomics and Epigenomics of Gestational Diabetes Mellitus: Understanding the Molecular Pathways of the Disease Pathogenesis.International journal of molecular sciences · 2022Review
- Article
- Nutrient Transporter Gene Expression in the Early Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy.Frontiers in cell and developmental biology · 2022Article
- Epigenetic Changes in Gestational Diabetes Mellitus.International journal of molecular sciences · 2021Review
- Embryonic cell migratory capacity is impaired upon exposure to glucose in vivo and in vitro.Birth defects research · 2019Article
- Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.Nature communications · 2019Article
- Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy.PloS one · 2019Article
- Maternal diabetes causes developmental delay and death in early-somite mouse embryos.Scientific reports · 2017Article
- Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes.Diabetes · 2017Article
- Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy.Scientific reports · 2017Article
- A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.Disease models & mechanisms · 2016Article
- Article
- Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain.Scientific reports · 2015Article
- Gene expression in teratogenic exposures: a new approach to understanding individual risk.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Modeling anterior development in mice: diet as modulator of risk for neural tube defects.American journal of medical genetics. Part C, Seminars in medical genetics · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Pregnancies complicated by maternal diabetes have long been known to carry a higher risk for congenital malformations, such as neural tube defects. Using the FVB inbred mouse strain and the Streptozotocin-induced diabetes model, we tested whether the incidence of neural tube defects in diabetic pregnancies can be modulated by maternal diet. In a comparison of two commercial mouse diets, which are considered nutritionally replete, we found that maternal consumption of the unfavorable diet was associated with a more than 3-fold higher rate of neural tube defects. Our results demonstrate that maternal diet can act as a modifier of the risk for abnormal development in high-risk pregnancies, and provide support for the possibility that neural tube defects in human diabetic pregnancies might be preventable by optimized maternal nutrition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.