ArticleBrain, behavior, and immunity2011
Nervous temperament in infant monkeys is associated with reduced sensitivity of leukocytes to cortisol's influence on trafficking.
Article in Brain, behavior, and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of Relocation, Social Housing Changes, and Diarrhea Status on Microbiome Composition of Juvenile Cynomolgus Macaques (Microorganisms · 2025Article
- Early-life behavioral features are associated with chronic emesis in rhesus macaques (Macaca mulatta).American journal of primatology · 2023Article
- Introducing individual sentience profiles in nonhuman primate neuroscience research.Current research in neurobiology · 2023Review
- The relationship of maternal rank, 5-HTTLPR genotype, and MAOA-LPR genotype to temperament in infant rhesus monkeys (Macaca mulatta).American journal of primatology · 2022Article
- Anterior Cingulate Cortex Ablation Disrupts Affective Vigor and Vigilance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Knowledge of Biobehavioral Organization Can Facilitate Better Science: A Review of the BioBehavioral Assessment Program at the California National Primate Research Center.Animals : an open access journal from MDPI · 2021Review
- Biobehavioral organization shapes the immune epigenome in infant rhesus Macaques (Macaca mulatta).Brain, behavior, and immunity · 2021Article
- Lipid metabolism is associated with temperament, corticosteroid, and hematological measures in infant rhesus monkeys (Zoological research · 2020Article
- Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats.Physiology & behavior · 2020Article
- Bridging the species gap in translational research for neurodevelopmental disorders.Neurobiology of learning and memory · 2019Article
- Paternal line effects of early experiences persist across three generations in rhesus macaques.Developmental psychobiology · 2018Article
- Personality, environmental stressors, and diarrhea in Rhesus macaques: An interactionist perspective.American journal of primatology · 2018Article
- Coping style and cortisol levels in infancy predict hair cortisol following new group formation in captive rhesus macaques (Macaca mulatta).American journal of primatology · 2018Article
- Control of Leukocyte Trafficking by Stress-Associated Hormones.Frontiers in immunology · 2018Review
- Social Influences on Prevotella and the Gut Microbiome of Young Monkeys.Psychosomatic medicine · 2017Article
- Do "birds of a feather flock together" or do "opposites attract"? Behavioral responses and temperament predict success in pairings of rhesus monkeys in a laboratory setting.American journal of primatology · 2017Article
- Responses to the Human Intruder Test are related to hair cortisol phenotype and sex in rhesus macaques (Macaca mulatta).American journal of primatology · 2017Article
- Genome-Wide Association Study between Single Nucleotide Polymorphisms and Flight Speed in Nellore Cattle.PloS one · 2016Article
- Article
- Depressogenic vulnerability and gender-specific patterns of neuro-immune dysregulation: What the ratio of cortisol to C-reactive protein can tell us about loss of normal regulatory control.Brain, behavior, and immunity · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
There is growing evidence that temperament/personality factors are associated with immune function and health-related outcomes. Neuroticism, in particular, is a risk-factor for several diseases, many with a strong inflammatory component. We propose that neuroticism (or nervous temperament in monkeys) is related to dysregulation of immune function by glucocorticoids. The present study tested the hypothesis that animals with a nervous temperament would show no relationship between cortisol concentrations and leukocyte numbers in peripheral blood (an easily obtainable measure of glucocorticoid-mediated immune function), while animals low on this factor would show expected relationships. Infant rhesus monkeys (n=1507) experienced a standardized testing procedure involving blood sampling, behavioral tests, and temperament ratings. Results confirmed the hypothesis: low-nervous animals showed the expected positive relationship between cortisol levels and neutrophil numbers, while high-nervous animals showed no relationship. High-nervous animals also showed elevated cortisol concentrations at most sample points, and responded to a human challenge with more negative emotional behavior. These data suggest that individuals with a nervous temperament show evidence of glucocorticoid desensitization of immune cells. Differences with other studies, including the specific types of leukocytes that are affected, are discussed, and implications for disease processes are suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.