ArticleHuman immunology2010
Donor-specific antibodies to human leukocyte antigens are associated with and precede antibodies to major histocompatibility complex class I-related chain A in antibody-mediated rejection and cardiac allograft vasculopathy after human cardiac transplantation.
Article in Human immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Antibodies to Non-HLA Antigens and Their Role in Organ Transplant Rejection.International journal of immunogenetics · 2026Review
- Heart transplantation and biomarkers: a review about their usefulness in clinical practice.Frontiers in cardiovascular medicine · 2024Review
- Extracellular Vesicles Mediate Immune Responses to Tissue-Associated Self-Antigens: Role in Solid Organ Transplantations.Frontiers in immunology · 2022Review
- Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease.Frontiers in immunology · 2022Article
- Vascular rejection in cardiac allograft vasculopathy: Impact on graft survival.Frontiers in cardiovascular medicine · 2022Article
- Balancing B cell responses to the allograft: implications for vaccination.Frontiers in immunology · 2022Review
- Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis.Transplant immunology · 2021Article
- Understanding the Correlation Between DSA, Complement Activation, and Antibody-Mediated Rejection in Heart Transplant Recipients.Transplantation · 2018Article
- Post-Transplant Natural Antibodies Associate with Kidney Allograft Injury and Reduced Long-Term Survival.Journal of the American Society of Nephrology : JASN · 2018Article
- Recent advances in allograft vasculopathy.Current opinion in organ transplantation · 2017Review
- Major Histocompatibility Complex Class I Chain-Related A (MICA) Molecules: Relevance in Solid Organ Transplantation.Frontiers in immunology · 2017Review
- Immune Responses to Tissue-Restricted Nonmajor Histocompatibility Complex Antigens in Allograft Rejection.Journal of immunology research · 2017Review
- Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection.Journal of immunology research · 2017Review
- Impact of Non-Human Leukocyte Antigen-Specific Antibodies in Kidney and Heart Transplantation.Frontiers in immunology · 2017Review
- B Cells, Antibodies, and More.Clinical journal of the American Society of Nephrology : CJASN · 2016Review
- Cardiac allograft vasculopathy: a donor or recipient induced pathology?Journal of cardiovascular translational research · 2015Review
- Role of MICA expression, anti-MICA antibodies and serum MICA during acute rejection in a rat-to-mouse cardiac transplantation model.International journal of clinical and experimental pathology · 2015Article
- Assessment of Immunological Biomarkers in the First Year after Heart Transplantation.Disease markers · 2015Article
- B cells mediate chronic allograft rejection independently of antibody production.The Journal of clinical investigation · 2014Article
- Interplay between immune responses to HLA and non-HLA self-antigens in allograft rejection.Human immunology · 2013Review
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Authors and funding
7 authors.
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Abstract
Humoral immune responses to mismatched donor human leukocyte antigen (HLA) and major histocompatibility complex (MHC) class I-related chain A (MICA) have been reported to contribute to immunopathogenesis of antibody-mediated rejection (AMR) in the early period and cardiac allograft vasculopathy (CAV) in the late period after cardiac transplantation (HTx). The goal of this study is to define the roles of donor-specific antibodies (DSA) and anti-MICA in AMR and CAV. A total of 95 post-HTx recipients were enrolled; 43 patients in the early period (≤ 12 months post-HTx) and 52 patients in the late period (>12 months post-HTx). Development of DSA and anti-MICA were serially monitored using Luminex. Development of DSA (AMR+: n = 6/8.75%, AMR-: n = 4/35.11%, p = 0.009) and anti-MICA (AMR+: n = 5/8.63%, AMR-: n = 4/35.11%, p = 0.002) was significantly associated with AMR. AMR+DSA+ patients demonstrated increased anti-MICA levels compared with AMR+DSA- patients (p=0.01). Serial monitoring revealed DSA (2.7 ± 1.4 months) preceded development of anti-MICA (6.5 ± 2.1 months) in recipients diagnosed with AMR at 8.3 ± 2.5 months post-HTx. Development of DSA (CAV+: n = 8/12.67%, CAV-: n = 5/40.13%, p = 0.004) and anti-MICA (CAV+: n = 9/12.75%, CAV-: n = 5/40.13%, p = 0.001) was significantly associated with CAV. CAV+DSA+ patients demonstrated increased anti-MICA levels compared with CAV+DSA- patients (p = 0.01). Antibodies to HLA are associated with and precede development of anti-MICA in AMR and CAV. Therefore, DSA and anti-MICA can be used as noninvasive markers for monitoring AMR and CAV.
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