ArticleBMC infectious diseases2010
A cohort study of Plasmodium falciparum infection dynamics in Western Kenya Highlands.
Article in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic diversity, population structure, and drug resistance of Plasmodium falciparum in Kenya: a systematic review and meta-analysis.Malaria journal · 2025Pooled it
- Dynamics of Afebrile Plasmodium falciparum Infections in Mozambican Men.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Trial
- Malaria Parasitemia and Parasite Density in Antiretroviral-Treated HIV-Infected Adults Following Discontinuation of Cotrimoxazole Prophylaxis.The Journal of infectious diseases · 2017Trial
- Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites.The American journal of tropical medicine and hygiene · 2014Trial
- Article
- Association Between Age and Plasmodium falciparum Infection Dynamics.American journal of epidemiology · 2019Article
- The persistence and oscillations of submicroscopic Plasmodium falciparum and Plasmodium vivax infections over time in Vietnam: an open cohort study.The Lancet. Infectious diseases · 2018Article
- Geographic-genetic analysis ofWellcome open research · 2017Article
- Existing Infection Facilitates Establishment and Density of Malaria Parasites in Their Mosquito Vector.PLoS pathogens · 2015Article
- Rapid response to selection, competitive release and increased transmission potential of artesunate-selected Plasmodium chabaudi malaria parasites.PLoS pathogens · 2014Article
- Marked variation in MSP-119 antibody responses to malaria in western Kenyan highlands.BMC infectious diseases · 2012Article
- Enhanced transmission of drug-resistant parasites to mosquitoes following drug treatment in rodent malaria.PloS one · 2012Article
- Progress towards understanding the ecology and epidemiology of malaria in the western Kenya highlands: opportunities and challenges for control under climate change risk.Acta tropica · 2012Review
- The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection.Journal of evolutionary biology · 2011Article
- The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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8 authors.
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Abstract
backgroundThe Kenyan highlands were malaria-free before the 1910s, but a series of malaria epidemics have occurred in the highlands of western Kenya since the 1980s. Longitudinal studies of the genetic structure, complexity, infection dynamics, and duration of naturally acquired Plasmodium falciparum infections are needed to facilitate a comprehensive understanding of malaria epidemiology in the complex Kenyan highland eco-epidemiological systems where malaria recently expanded, as well as the evaluation of control measures.
methodsWe followed a cohort of 246 children residing in 3 villages at altitudes 1430 - 1580 m in western Kenya. Monthly parasitological surveys were undertaken for one year, yielding 866 P. falciparum isolates that were analyzed using 10 microsatellite markers.
resultsInfection complexity and genetic diversity were high (HE = 0.787-0.816), with ≥83% of infections harboring more than one parasite clone. Diversity remained high even during the low malaria transmission season. There was no significant difference between levels of genetic diversity and population structure between high and low transmission seasons. Infection turn-over rate was high, with the average infection duration of single parasite genotypes being 1.11 months, and the longest genotype persistence was 3 months.
conclusionsThese data demonstrate that despite the relatively recent spread of malaria to the highlands, parasite populations seem to have stabilized with no evidence of bottlenecks between seasons, while the ability of residents to clear or control infections indicates presence of effective anti-plasmodial immune mechanisms.
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