ArticleCardiovascular diabetology2010
Abnormalities in circadian blood pressure variability and endothelial function: pragmatic markers for adverse cardiometabolic profiles in asymptomatic obese adults.
Article in Cardiovascular diabetology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Prediabetes and associated disorders.Endocrine · 2015Review
- Regulation of obesity and insulin resistance by nitric oxide.Free radical biology & medicine · 2014Review
- Antiobesogenic role of endothelial nitric oxide synthase.Vitamins and hormones · 2014Article
- Cardiovascular risk escalation with caloric excess: a prospective demonstration of the mechanics in healthy adults.Cardiovascular diabetology · 2013Article
- Relationship of visit-to-visit and ambulatory blood pressure variability to vascular function in African Americans.Hypertension research : official journal of the Japanese Society of Hypertension · 2012Article
- Dysglycemia induces abnormal circadian blood pressure variability.Cardiovascular diabetology · 2011Article
- Relationship of autonomic imbalance and circadian disruption with obesity and type 2 diabetes in resistant hypertensive patients.Cardiovascular diabetology · 2011Article
- Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes.Cardiovascular diabetology · 2011Article
- Insulin resistance and circadian rhythm of cardiac autonomic modulation.Cardiovascular diabetology · 2010Article
- Fibrinogen and associated risk factors in a high-risk population: urban Indigenous Australians, the DRUID Study.Cardiovascular diabetology · 2010Article
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6 authors.
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Abstract
backgroundCardiovascular disease (CVD) risk, although perceived to be high, is often difficult to demonstrate in disease free (healthy) obese adults. HYPOTHESIS: Changes in circadian blood pressure variability (CBPV) and endothelial function (EF) may be early correlates of cardiometabolic disorders.
methodsAsymptomatic men and women in 3 groups: normal weight (n = 10), overweight (n = 10) and obese (n = 15) were evaluated. Blood pressure and heart rate were recorded over 7 days: every 30 minutes during the day and every 60 minutes during the night, by automatic ambulatory monitoring. Resting EF was assessed in a fasting state between 8-10 AM by brachial ultrasound. Anthropometric and cardiometabolic indicators were measured and correlations with CBPV and EF were investigated.
resultsThe 3 groups had (Mean(SD)) BMI: 22.6(1.6), 27(3) and 34(5) kg/m2, respectively, weight: 64(16), 79(14), 95(16) kg and waist circumference: 79(9), 93(10), 107(13) cm. None in normal-weight or overweight groups had abnormal CBPV, while 8 of 15 obese adults had one or more CBPV abnormities (p < 0.05). Obese adults with CBPV abnormalities had elevated hs-CRP (15.3(9.3) mg/L), fibrinogen (593(97) mg/dl), fasting serum glucose (102(16) mg/dL), and cardiac risk ratios (Total-C/HDL-C: 5.2(1.9), LDL-C/HDL-C: 3.1(1.4)). Adults in the 3 respective groups who did not have CBPV abnormalities had flow-mediated brachial artery dilatation (FMD) of 0.22(0.06); 0.20(0.04), 0.23(0.02) mm over resting diameter. Obese participants with CBPV abnormalities (Mesor-hypotension, circadian hyper amplitude tension, elevated pulse pressure), had attenuated FMD at 78, 52, and 56% of resting reference diameter (means 0.18(0.07), 0.12(0.08), and 0.13(0.05) mm; p < 0.05), respectively.
conclusionsAsymptomatic obese adults with abnormal CBPV and EF exhibit unfavorable cardiometabolic profiles.
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