ReviewRegenerative medicine2010
Cardiac regeneration using human embryonic stem cells: producing cells for future therapy.
Review in Regenerative medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Embryonic Stem Cells in Clinical Trials: Current Overview of Developments and Challenges.Advances in experimental medicine and biology · 2021Review
- Regenerative Therapy for Cardiomyopathies.Journal of cardiovascular translational research · 2018Review
- Hepatocyte Transplantation: Cell Sheet Technology for Liver Cell Transplantation.Current transplantation reports · 2017Review
- Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases.Stem cells international · 2016Review
- Safety of human embryonic stem cells in patients with terminal/incurable conditions- a retrospective analysis.Annals of neurosciences · 2015Article
- Recent development of temperature-responsive surfaces and their application for cell sheet engineering.Regenerative biomaterials · 2014Review
- Coaxial electrospray of liquid core-hydrogel shell microcapsules for encapsulation and miniaturized 3D culture of pluripotent stem cells.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- Considerations in designing systems for large scale production of human cardiomyocytes from pluripotent stem cells.Stem cell research & therapy · 2014Review
- Bioengineering heart tissue for in vitro testing.Current opinion in biotechnology · 2013Review
- Constraining the Pluripotent Fate of Human Embryonic Stem Cells for Tissue Engineering and Cell Therapy - The Turning Point of Cell-Based Regenerative Medicine.British biotechnology journal · 2013Article
- Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery and disease modeling: from the genetic, epigenetic, and tissue modeling perspectives.Stem cell research & therapy · 2013Review
- Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart.Cardiovascular diabetology · 2013Article
- Stem cells for cardiac repair: an introduction.Journal of geriatric cardiology : JGC · 2013Article
- Natural ECM as biomaterial for scaffold based cardiac regeneration using adult bone marrow derived stem cells.Stem cell reviews and reports · 2013Review
- Theranostic effect of serial manganese-enhanced magnetic resonance imaging of human embryonic stem cell derived teratoma.Magnetic resonance in medicine · 2012Article
- Strategies for enrichment and selection of stem cell-derived tissue precursors.Stem cell research & therapy · 2012Review
- Defining Conditions for Sustaining Epiblast Pluripotence Enables Direct Induction of Clinically-Suitable Human Myocardial Grafts from Biologics-Free Human Embryonic Stem Cells.Journal of clinical & experimental cardiology · 2012Article
- Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition.Cytotherapy · 2012Article
- Review
- High-throughput tracking of pluripotent human embryonic stem cells with dual fluorescence resonance energy transfer molecular beacons.Stem cells and development · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. Because of their ability to differentiate into any cell type in the body, hESCs offer a novel therapeutic paradigm for myocardial repair by furnishing a supply of cardiomyocytes (CMs) that would ultimately restore normal myocardial function when delivered to the damaged heart. Spontaneous CM differentiation of hESCs is an inefficient process that yields very low numbers of CMs. In addition, it is not clear that fully differentiated CMs provide the benefits sought from cell transplantation. The need for new methods of directed differentiation of hESCs into functional CMs and cardiac progenitors has led to an explosion of research utilizing chemical, genetic, epigenetic and lineage selection strategies to direct cardiac differentiation and enrich populations of cardiac cells for therapeutic use. Here, we review these approaches and highlight their increasingly important roles in stem cell biology and cardiac regenerative medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.