ArticleThe Journal of infectious diseases2010
Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
95 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Global research trends in neurosyphilis: a bibliometric analysis from 2010 to 2024.Frontiers in immunology · 2025Pooled it
- Risk factors of serofast state in patients undergoing syphilis: a meta-analysis of 17 cohort studies.Frontiers in immunology · 2025Pooled it
- Molecular typing of Treponema pallidum: a systematic review and meta-analysis.PLoS neglected tropical diseases · 2011Pooled it
- Trial
- Phylo-Plex: a phylogenetically informed, low-cost amplicon sequencing platform for deployable high-resolution genomic epidemiology.Nature communications · 2026Article
- Molecular characterization of Treponema pallidum-related rabbit-derived material following experimental inoculation with human chancre-derived clinical specimens: a pilot exploratory study.BMC microbiology · 2026Article
- Investigation of bacterial agents in yaws-like ulcers in children and their environment in Cameroon: An experience from the Akonolinga Health District.PLoS neglected tropical diseases · 2026Article
- Formal description ofInternational journal of systematic and evolutionary microbiology · 2026Article
- Article
- Detection ofMicrobiology spectrum · 2026Article
- Reported Neurologic Manifestations Among Persons With Syphilis by Stage of Infection-12 States, 2019-2022.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Review
- Article
- Mapping the distribution of yaws and Haemophilus ducreyi in the western north region of Ghana.BMC infectious diseases · 2025Observational
- Latent class analysis and machine learning for clinical subtyping prediction and differentiation in suspected neurosyphilis patients.Frontiers in cellular and infection microbiology · 2025Article
- Decoding and Unravelling Mpox, Herpes, and Syphilis Infections: A State of Art Review.Current pharmaceutical biotechnology · 2025Review
- Prospective evaluation of non-invasive saliva specimens for the diagnosis of syphilis and molecular surveillance ofJournal of clinical microbiology · 2024Article
- Molecular investigation ofMicrobiology spectrum · 2024Article
- Article
- Typing of Treponema pallidum in a Brazilian sample and follow-up of treatment using molecular assays.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundStrain typing is a tool for determining the diversity and epidemiology of infections.
methodsTreponema pallidum DNA was isolated from 158 patients with syphilis from the United States, China, Ireland, and Madagascar and from 15 T. pallidum isolates. Six typing targets were assessed: (1) the number of 60‐bp repeats in the acidic repeat protein gene, (2) restriction fragment length polymorphism (RFLP) analysis of T. pallidum repeat (tpr) subfamily II genes, (3) RFLP analysis of the tprC gene, (4) determination of tprD allele in the tprD gene locus, (5) the presence of a 51‐bp insertion between tp0126 and tp0127, and (6) sequence analysis of an 84‐bp region of tp0548. The combination of targets 1 and 2 comprises the Centers for Disease Control and Prevention (CDC) T. pallidum subtyping method.
resultsAdding sequence analysis of tp0548 to the CDC method yielded the most discriminating typing system. Twenty‐five strain types were identified and designated as "CDC subtype/tp0548 sequence type." Type 14d/f was found in samples from 5 of 6 locations. In Seattle, Washington, strain types changed from 1999 through 2008 (P < .001). Twenty‐one (50%) of 42 patients infected with type 14d/f had neurosyphilis compared with 10 (24%) of 41 patients infected with any of the other types combined (P = .02).
conclusionWe describe an enhanced T. pallidum strain typing system that shows biological and clinical relevance.
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