ArticleAmerican journal of human biology : the official journal of the Human Biology Council
Life history, immune function, and intestinal helminths: Trade-offs among immunoglobulin E, C-reactive protein, and growth in an Amazonian population.
Article in American journal of human biology : the official journal of the Human Biology Council. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 111 citations in OpenAlex.
- Tradeoffs between immune function and childhood growth among Amazonian forager-horticulturalists.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Navigating Practical, Political, and Ethical Challenges of Long-Term Human Biology Field Research: The Shuar Health and Life History Project.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- The emergence of cooperative behaviors, norms, and strategies across five diverse societies.Science advances · 2026Article
- The Shuar Health and Life History Project: Overview at 20 Years and Introduction to the Special Issue.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Amazonian Shuar testosterone levels are related to parasite infection: immunocompetence handicap hypothesis implications.Evolution, medicine, and public health · 2026Article
- Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon.Proceedings. Biological sciences · 2025Article
- Soil-Transmitted Helminths and the Intricacies of Immunoregulation: Evidence From Amazonian Ecuador for the Importance of Considering Species-Specific Effects Within the Old Friends Hypothesis.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Circulating Epstein-Barr Virus Antibody Levels as a Biomarker of Socioecological Adversity in Amazonian Ecuador.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Poorer Longitudinal Growth Among HIV Exposed Compared With Unexposed Infants in Kenya.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Seasonality and Differential Growth Patterns of Body Dimensions of Children in a Rural Community of Yucatan, Mexico.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Chronic Stress and Severe Water Insecurity During the Historic 2022 Drought in Northern Kenya Were Associated With Inflammation Among Daasanach Seminomadic Pastoralists.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Contemporary small-scale subsistence populations offer unique insights into human musculoskeletal health and aging.Science advances · 2024Review
- Rural Embodiment and Community Health: an Anthropological Case Study on Biocultural Determinants of Tropical Disease Infection and Immune System Development in the USA.Current tropical medicine reports · 2023Review
- Ecoimmunology in the field: Measuring multiple dimensions of immune function with minimally invasive, field-adapted techniques.American journal of human biology : the official journal of the Human Biology Council · 2022Review
- Minimally invasive biomarkers in human and non-human primate evolutionary biology: Tools for understanding variation and adaptation.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- Early life, life course and gender influences on levels of C-reactive protein among migrant Bangladeshis in the UK.Evolution, medicine, and public health · 2022Article
- Pathogen disgust sensitivity protects against infection in a high pathogen environment.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Women's socioeconomic position in ontogeny is associated with improved immune function and lower stress, but not with height.Scientific reports · 2020Article
- Old friends meet a new foe: A potential role for immune-priming parasites in mitigating COVID-19 morbidity and mortality.Evolution, medicine, and public health · 2020Review
- Market integration and soil-transmitted helminth infection among the Shuar of Amazonian Ecuador.PloS one · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesInfection with helminths is associated with shifts in host immunity, including increased production of immunoglobulin E (IgE) and reduced inflammation. Given limited energy budgets, these shifts may involve changes in energy allocation toward competing demands. Here we test for potential trade-offs between growth, IgE, and the inflammatory marker C-reactive protein (CRP).
methodsDried blood spots and anthropometrics were collected from 162 Shuar forager-horticulturalists from a village in southeastern Ecuador. Enzyme-linked immunosorbent assays (ELISAs) were used to measure IgE and CRP. Relationships among IgE, CRP, and anthropometrics were examined in three groups: children aged 2-7 years (n = 63), children aged 8-15 (n = 61), and adults over age 18 (n = 37).
resultsGeometric mean IgE was 1,196 IU ml⁻¹ while geometric mean CRP was 1.33 mg l⁻¹. In children, IgE and CRP were negatively correlated (r = -0.21, P = 0.02, df = 122). Controlling for fat stores and age, IgE was associated with lower stature in children (t = -2.04, P = 0.04, df = 109), and adults (t = -3.29, P < 0.01, df = 33). In children there was a significant interaction between age and CRP, such that in younger children CRP was associated with shorter stature, but in older children was associated with greater stature (t = 2.15, P = 0.04, df = 109).
conclusionsThese results suggest that infection with helminths may have hidden costs associated with immunological changes, and that these costs may ultimately affect growth and other life history parameters.
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