ArticleSleep & breathing = Schlaf & Atmung2011
Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor protein, cortisol, and lipid levels.
Article in Sleep & breathing = Schlaf & Atmung, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02325687 (A Pilot Study of Biomarkers in Obstructive Sleep Apnea), which is not on this map. Cited by 25 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study of Biomarkers in Obstructive Sleep Apnea (OSA): Is There a Correlation Between Cerebrospinal Fluid and Serum Markers of Inflammation in OSA?
Who cites it
25 citing papers in PubMed, 6 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Diagnostic utility of obstructive sleep apnea screening questionnaires: a comprehensive meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Association between brain-derived neurotrophic factor levels and obstructive sleep apnea: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Gender Differences in the Context of Obstructive Sleep Apnea and Metabolic Diseases.Frontiers in physiology · 2021Pooled it
- Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis.Frontiers in endocrinology · 2020Pooled it
- Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Pooled it
- Is obstructive sleep apnea associated with cortisol levels? A systematic review of the research evidence.Sleep medicine reviews · 2012Pooled it
- Sleep apnoea and the hypothalamic-pituitary-adrenal axis in men and women: effects of continuous positive airway pressure.The European respiratory journal · 2016Trial
- Sex differences in endocrine, metabolic and psychological disturbance in obese patients with OSA.Biology of sex differences · 2025Article
- Twelve-Month CPAP Therapy Modulates BDNF Levels in Patients with Severe Obstructive Sleep Apnea: Implications for Metabolic and Treatment Compliance.International journal of molecular sciences · 2025Article
- The Complex Relationship between Neuromodulators, Circadian Rhythms, and Insomnia in Patients with Obstructive Sleep Apnea.International journal of molecular sciences · 2024Article
- Neurotrophins in the Neuropathophysiology, Course, and Complications of Obstructive Sleep Apnea-A Narrative Review.International journal of molecular sciences · 2023Review
- BDNF and proBDNF Serum Protein Levels in Obstructive Sleep Apnea Patients and Their Involvement in Insomnia and Depression Symptoms.Journal of clinical medicine · 2022Article
- Evaluation of HIF-1 Involvement in the BDNF and ProBDNF Signaling Pathways among Obstructive Sleep Apnea Patients.International journal of molecular sciences · 2022Article
- Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing.Frontiers in pediatrics · 2022Article
- The evaluation of serum brain-derived neurotrophic factor and neurofilament light chain levels in patients with obstructive sleep apnea syndrome.Laryngoscope investigative otolaryngology · 2021Article
- Circadian Biology in Obstructive Sleep Apnea.Diagnostics (Basel, Switzerland) · 2021Review
- Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients.PloS one · 2020Article
- Serum testosterone/cortisol ratio in people with obstructive sleep apnea.Journal of clinical laboratory analysis · 2020Article
- Altered irisin/BDNF axis parallels excessive daytime sleepiness in obstructive sleep apnea patients.Respiratory research · 2019Article
- Obstructive Sleep Apnea in Gestational Diabetes: A Pilot Study of the Role of the Hypothalamic-Pituitary-Adrenal Axis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesObstructive sleep apnea (OSA) is a sleep-disordered breathing leading to vascular endothelial cells dysfunction, cognitive impairment, and abnormal lipid metabolism. serum brain-derived neurotrophic factor (BDNF) protein, cortisol, and lipid levels in OSA were investigated. MATERIALS AND
methodsAll middle-aged subjects including healthy individuals without signs and symptoms of apnea-hypopnea and ear nose throat (ENT) outpatients were randomly recruited and screened by overnight polysomnogram (PSG). Apnea-hypopnea index (AHI) was used as a criteria to determine subjects to enroll in this program. According to AHI, they were separated into control and OSA groups. A group of 39 OSA patients (AHI ≥ 10 events/h) and 24 control subjects (AHI < 5 events/h) were selected. Serum BDNF protein was analyzed by enzyme-linked immunosorbent assay (ELISA) from venous blood collection at 8:00 a.m. following PSG. Serum cortisol was assayed by enzyme-chemiluminescense immuno assay (ECLIA). Serum lipid profile levels were determined by enzymatic colorimetric and homogeneous method.
resultsCharacteristics of OSA patients and control groups including gender, age, AHI, body weight, height, and BMI showed significant differences. Serum BDNF protein, cortisol, triglyceride, and total cholesterol levels in OSA and control groups were not significantly different. High density lipoprotein-cholesterol (HDL-c) in OSA was significantly lower than that of control (p = 0.008) while low density lipoprotein-cholesterol (LDL-c) was significantly higher than that of control (p = 0.04).
conclusionsOSA had no significant effect on serum BDNF, cortisol, triglyceride, or total cholesterol levels while LDL-c and HDL-c levels in OSA patients compared to control were significantly different at p = 0.04, and p = 0.008, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.