ArticleLasers in medical science2011
Effects of low-power laser irradiation (LPLI) at different wavelengths and doses on oxidative stress and fibrogenesis parameters in an animal model of wound healing.
Article in Lasers in medical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Alveolar Bone Preservation After Molar Extraction Using Photobiomodulation Combined With Grafting With Scaffold Biomaterial: Clinical, Randomized, Triple-blind Study.
Evaluation of Alveolar Bone Preservation After Early Molar Extraction Using Photobiomodulation Combined With Grafting With Scaffold Biomaterial: Clinical, Randomized, Triple-blind Study.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Effect of Laser Therapy on Postoperative Pain and Endodontic Retreatment: A Systematic Review and Meta-Analysis.International dental journal · 2024Pooled it
- A systematic review and meta-analysis on the efficacy of low-level laser therapy in the management of complication after mandibular third molar surgery.Lasers in medical science · 2015Pooled it
- Efficacy of low-level laser therapy in the management of orthodontic pain: a systematic review and meta-analysis.Lasers in medical science · 2013Pooled it
- Trial
- Effect of photobiomodulation with low-level laser therapy combined with potassium nitrate on controlling post-bleaching tooth sensitivity: clinical, randomized, controlled, double-blind, and split-mouth study.Clinical oral investigations · 2019Trial
- Effect of low-level laser therapy on tooth-related pain and somatosensory function evoked by orthodontic treatment.International journal of oral science · 2018Trial
- Low-level laser therapy as an adjunct to conventional therapy in the treatment of diabetic foot ulcers.Lasers in medical science · 2017Trial
- Effect of the transdermal low-level laser therapy on endothelial function.Lasers in medical science · 2016Trial
- Evaluation of the use of low-level laser therapy in pain control in orthodontic patients: A randomized split-mouth clinical trial.The Angle orthodontist · 2016Trial
- Effect of low-level laser therapy after extraction of impacted lower third molars.Lasers in medical science · 2013Trial
- Efficacy of low-level laser therapy in the management of pain, facial swelling, and postoperative trismus after a lower third molar extraction. A preliminary study.Lasers in medical science · 2012Trial
- Effects of Low-Level Light Therapy (LLLT) on Oxidative Stress in the Cutaneous Healing Process: A Literature Review.Journal of lasers in medical sciences · 2026Review
- Dose-dependent effects of yellow laser irradiation on Viability, apoptosis, and ROS generation in cell lines from breast cancer.Lasers in medical science · 2025Article
- Effects of Low-Level Laser Therapy on Oral Mucosal Wound Healing and Systemic Oxidative Stress in Diabetic Rats: An In Vivo Experimental Study.Medicina (Kaunas, Lithuania) · 2025Article
- Influence of biopolymer based gold nanoparticles and photobiomodulation in in vitro wound healing.Scientific reports · 2025Article
- Diabetic rats skin wounds treated with heterologous fibrin sealant followed by photobiomodulation therapy.Lasers in medical science · 2024Article
- The impact of antimicrobial photodynamic therapy on pain and oral health-related quality of life: A literature review.Journal of dental sciences · 2024Review
- Radioreparative Effect of Diode Laser on Leukopoiesis Recovery: A Pilot Study.Life (Basel, Switzerland) · 2024Article
- The Effects and Mechanisms of PBM Therapy in Accelerating Orthodontic Tooth Movement.Biomolecules · 2023Review
- Low-power laser in increasing doses improve wound healing process in rats.Lasers in medical science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gallium-arsenide (GaAs) and helium-neon (HeNe) lasers are the most commonly used low-energy lasers in physiotherapy for promoting wound healing and pain modulation. The aim of this study was investigate the effect of low-power laser irradiation (LPLI) at different wavelengths and doses on oxidative stress and fibrogenesis parameters in an animal model of wound healing. The animals were randomly divided into five groups (n=6): Controls (skin injured animals without local or systemic treatment), skin injury treated with HeNe 1 J/cm(2) (two seg); skin injury treated with HeNe 3 J/cm(2) (six seg); skin injury treated with GaAs 1 J/cm(2) (three seg); skin injury treated with GaAs 3 J/cm(2) (nine seg). A single circular wound measuring 8 mm in diameter was surgically created on the back of the animal. The rats were irradiated at 2, 12, 24, 48, 72, 96, and 120 h after skin injury. The parameters, namely hydroxyproline content, activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), and lipid (TBARS) and protein oxidation (carbonyl groups) measurements were assessed. In addition, wound size regression was also analyzed. The results showed an improvement in the wound healing reflected by the reduction in wound size and increased collagen synthesis. Moreover, a significant reduction in TBARS levels, carbonyl content, and SOD and CAT activities were observed after laser irradiation, particularly with the treatments HeNe laser 1 and 3 J/cm(2) dose and GaAs 3 J/cm(2) dose. The data strongly indicate that LPLI therapy is efficient in accelerating the skin wound healing process after wounding, probably by reducing the inflammatory phase and inducing collagen synthesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.