ArticlePLoS computational biology2010
Evolution under fluctuating environments explains observed robustness in metabolic networks.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Stoichiometric Modeling of Artificial String Chemistries Reveals Constraints on Metabolic Network Structure.Journal of molecular evolution · 2021Article
- Comparative study between discrete and continuum models for the evolution of competing phenotype-structured cell populations in dynamical environments.Physical review. E · 2020Article
- Article
- Article
- How to deal with parameters for whole-cell modelling.Journal of the Royal Society, Interface · 2017Review
- Characterizing the roles of changing population size and selection on the evolution of flux control in metabolic pathways.BMC evolutionary biology · 2017Article
- Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable.Biology direct · 2016Article
- Survival of the Curviest: Noise-Driven Selection for Synergistic Epistasis.PLoS genetics · 2016Article
- Cellular Growth Arrest and Persistence from Enzyme Saturation.PLoS computational biology · 2016Article
- A Model of Genome Size Evolution for Prokaryotes in Stable and Fluctuating Environments.Genome biology and evolution · 2015Article
- A Philosophical Perspective on Evolutionary Systems Biology.Biological theory · 2015Article
- A network characteristic that correlates environmental and genetic robustness.PLoS computational biology · 2014Article
- Gene network requirements for regulation of metabolic gene expression to a desired state.Scientific reports · 2013Article
- Article
- Convergent evolution of modularity in metabolic networks through different community structures.BMC evolutionary biology · 2012Article
- An in silico platform for the design of heterologous pathways in nonnative metabolite production.BMC bioinformatics · 2012Article
- An equilibrium for phenotypic variance in fluctuating environments owing to epigenetics.Journal of the Royal Society, Interface · 2012Article
- Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.PloS one · 2012Article
- Systems-biology approaches for predicting genomic evolution.Nature reviews. Genetics · 2011Review
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Abstract
A high level of robustness against gene deletion is observed in many organisms. However, it is still not clear which biochemical features underline this robustness and how these are acquired during evolution. One hypothesis, specific to metabolic networks, is that robustness emerges as a byproduct of selection for biomass production in different environments. To test this hypothesis we performed evolutionary simulations of metabolic networks under stable and fluctuating environments. We find that networks evolved under the latter scenario can better tolerate single gene deletion in specific environments. Such robustness is underlined by an increased number of independent fluxes and multifunctional enzymes in the evolved networks. Observed robustness in networks evolved under fluctuating environments was "apparent," in the sense that it decreased significantly as we tested effects of gene deletions under all environments experienced during evolution. Furthermore, when we continued evolution of these networks under a stable environment, we found that any robustness they had acquired was completely lost. These findings provide evidence that evolution under fluctuating environments can account for the observed robustness in metabolic networks. Further, they suggest that organisms living under stable environments should display lower robustness in their metabolic networks, and that robustness should decrease upon switching to more stable environments.
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