ArticlePloS one2010
CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 119 citations in OpenAlex.
- Salt Treatment Confers Protection Against Acute Carp Edema Virus Reinfection While Promoting Viral Persistence.Journal of fish diseases · 2026Article
- St John's Wort (Hypericum perforatum) Oil on Immune Response, Growth Performance and Bacterial Resistance Against Lactococcus garvieae Pathogen in Rainbow Trout (Oncorhynchus mykiss).Journal of fish diseases · 2026Article
- Transcriptional Profiling of Common Carp: A Microarray-Based Framework for Aquaculture Research.International journal of molecular sciences · 2025Article
- Detection and Localization of IL-8 and CXCR1 in Rainbow Trout Larvae in Response toAnimals : an open access journal from MDPI · 2024Article
- Evolutionarily conserved mechanisms regulating stress-induced neutrophil redistribution in fish.Frontiers in immunology · 2024Article
- Acute immune responses in zebrafish and evasive behavior of a parasite - who is winning?Frontiers in cellular and infection microbiology · 2023Article
- Commensal and Opportunistic Bacteria Present in the Microbiota in Atlantic Cod (Microorganisms · 2021Article
- Biofilm Produced In Vitro byMicroorganisms · 2020Article
- Comparative Characterization of TwoBiomolecules · 2020Article
- Molecular Identification and Dual Functions of Two Different CXC Chemokines in Nile Tilapia (Microorganisms · 2020Article
- Molecular Characterization and Chemotactic Function of CXCL8 in Northeast Chinese Lamprey (Frontiers in immunology · 2020Article
- Different transcriptional response between susceptible and resistant common carp (Cyprinus carpio) fish hints on the mechanism of CyHV-3 disease resistance.BMC genomics · 2019Article
- Paralogs of Common Carp Granulocyte Colony-Stimulating Factor (G-CSF) Have Different Functions Regarding Development, Trafficking and Activation of Neutrophils.Frontiers in immunology · 2019Article
- Amphibian (Frontiers in immunology · 2018Article
- CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment.The Journal of experimental medicine · 2017Article
- Cxcl8b and Cxcr2 Regulate Neutrophil Migration through Bloodstream in Zebrafish.Journal of immunology research · 2017Article
- Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling.Oncogene · 2015Article
- Teleost Chemokines and Their Receptors.Biology · 2015Review
- Polish Scientists in Fish Immunology: A Short History.Biology · 2015Review
- Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the inflammatory process, chemokine CXCL8 plays a pivotal role in recruitment of human neutrophilic granulocytes. A diversity of sequences similar to CXCL8 was reported in fish, but their evolutionary relationships and functional homology with their human homolog remain unclear. PRINCIPAL
findingsWe screened fish genomes to seek for sequences related to CXCL8. A first lineage was retrieved in all teleosts, while a second CXCL8 lineage was found in zebrafish and carp only. An early inflammatory function for both lineages was indicated by several lines of evidence. The induction of carp CXCL8s, CXCb, and CXC receptor-1 and -2 was analyzed after in vitro stimulation of leukocyte subpopulations and in two in vivo inflammation models. Recombinant proteins of carp CXCL8 proteins were produced and showed significant chemotactic activity for carp leukocytes.
conclusionsWhile both carp CXCL8s appear to be functional homologs of mammalian CXCL8, their different induction requirements and kinetics evoke a gene-specific sub-functionalization.
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