ReviewMolecular systems biology2010
A comprehensive molecular interaction map of the budding yeast cell cycle.
Review in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- A yeast cell cycle model integrating stress, signaling, and physiology.FEMS yeast research · 2022Article
- DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.Microbiology spectrum · 2022Article
- Cyclin/Forkhead-mediated coordination of cyclin waves: an autonomous oscillator rationalizing the quantitative model of Cdk control for budding yeast.NPJ systems biology and applications · 2021Review
- A Dynamical Paradigm for Molecular Cell Biology.Trends in cell biology · 2020Review
- Genetic interactions derived from high-throughput phenotyping of 6589 yeast cell cycle mutants.NPJ systems biology and applications · 2020Article
- Clb3-centered regulations are recurrent across distinct parameter regions in minimal autonomous cell cycle oscillator designs.NPJ systems biology and applications · 2020Article
- A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae.Nature communications · 2019Article
- Clustering approaches for visual knowledge exploration in molecular interaction networks.BMC bioinformatics · 2018Article
- Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma.Life science alliance · 2018Article
- Modeling of the jasmonate signaling pathway in Arabidopsis thaliana with respect to pathophysiology of Alternaria blight in Brassica.Scientific reports · 2017Article
- Quantitative Systems Biology to decipher design principles of a dynamic cell cycle network: the "Maximum Allowable mammalian Trade-Off-Weight" (MAmTOW).NPJ systems biology and applications · 2017Review
- The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulation.Nucleic acids research · 2016Article
- Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate.Nature communications · 2016Article
- Network analyses based on comprehensive molecular interaction maps reveal robust control structures in yeast stress response pathways.NPJ systems biology and applications · 2016Article
- Influence of parameter values on the oscillation sensitivities of two p53-Mdm2 models.Systems and synthetic biology · 2015Article
- The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms.BMC systems biology · 2015Article
- Bud-Localization of CLB2 mRNA Can Constitute a Growth Rate Dependent Daughter Sizer.PLoS computational biology · 2015Article
- Overview of the Cancer Genetics and Pathway Curation tasks of BioNLP Shared Task 2013.BMC bioinformatics · 2015Article
- Network reconstruction and validation of the Snf1/AMPK pathway in baker's yeast based on a comprehensive literature review.NPJ systems biology and applications · 2015Article
- Computational analyses of synergism in small molecular network motifs.PLoS computational biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the accumulation of data on complex molecular machineries coordinating cell-cycle dynamics, coupled with its central function in disease patho-physiologies, it is becoming increasingly important to collate the disparate knowledge sources into a comprehensive molecular network amenable to systems-level analyses. In this work, we present a comprehensive map of the budding yeast cell-cycle, curating reactions from ∼600 original papers. Toward leveraging the map as a framework to explore the underlying network architecture, we abstract the molecular components into three planes--signaling, cell-cycle core and structural planes. The planar view together with topological analyses facilitates network-centric identification of functions and control mechanisms. Further, we perform a comparative motif analysis to identify around 194 motifs including feed-forward, mutual inhibitory and feedback mechanisms contributing to cell-cycle robustness. We envisage the open access, comprehensive cell-cycle map to open roads toward community-based deeper understanding of cell-cycle dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.