ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2010
Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Determination of the discriminant score of intestinal microbiota as a biomarker of disease activity in patients with ulcerative colitis.BMC gastroenterology · 2014Trial
- Dietary supplementation of endo-1,4-ß-D-mannanase improves turkey growth through enhancement of immune response and jejunal barrier integrity.Poultry science · 2026Article
- Oral Microbiome-Derived Proteins in Brain Extracellular Vesicles Circulate and Tie to Specific Dysbiotic and Neuropathological Profiles in Age-Related Dementias.Molecular & cellular proteomics : MCP · 2025Article
- The Multiple Roles of Heat Shock Proteins in the Development of Inflammatory Bowel Disease.Current molecular medicine · 2025Review
- Link Between Oral and Gut Microbiomes: The Oral-Gut Axis.Advances in experimental medicine and biology · 2025Review
- Decoding host-microbiome interactions through co-expression network analysis within the non-human primate intestine.mSystems · 2024Article
- Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR).Cell stress & chaperones · 2024Review
- Epithelial Heat Shock Proteins Mediate the Protective Effects ofFrontiers in immunology · 2022Article
- The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus.International journal of molecular sciences · 2021Review
- Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience.Neurobiology of disease · 2020Review
- Increases in Colonic Bacterial Diversity after ω-3 Fatty Acid Supplementation Predict Decreased Colonic Prostaglandin E2 Concentrations in Healthy Adults.The Journal of nutrition · 2019Article
- Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Interactions of Gut Microbiota, Endotoxemia, Immune Function, and Diet in Exertional Heatstroke.Journal of sports medicine (Hindawi Publishing Corporation) · 2018Review
- Current Perspectives of the Chicken Gastrointestinal Tract and Its Microbiome.Computational and structural biotechnology journal · 2018Review
- Microbiota profile in new-onset pediatric Crohn's disease: data from a non-Western population.Gut pathogens · 2018Article
- Dietary fat and fiber interactively modulate apoptosis and mitochondrial bioenergetic profiles in mouse colon in a site-specific manner.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2017Article
- Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice.Mucosal immunology · 2017Article
- Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.Scientific reports · 2016Article
- Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota.Nutrition reviews · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Cytoprotective heat shock proteins (Hsps) are critical for intestinal homeostasis and are known to be decreased in inflammatory bowel diseases. Signals responsible for maintenance of Hsp expression are incompletely understood. In this study, we find that Hsp25/27 and Hsp70 protein expressions are differentially regulated along the longitudinal length of the large intestine, being highest in the proximal colon and decreasing to the distal colon. This longitudinal gradient was similar in both conventionally colonized mouse colon as well as biopsies of human proximal and distal colon but was abolished in the colon of germ-free mice, suggesting a role of intestinal microbiota in the Hsp regional expression. Correspondingly, analysis of 16S ribosomal RNA genes of bacteria from each colonic segment indicated increased bacterial richness and diversity in the proximal colon. The mechanism of regulation is transcriptional, as Hsp70 mRNA followed a similar pattern to Hsp70 protein expression. Lysates of mucosa-associated bacteria from the proximal colon stimulated greater Hsp25 and Hsp70 mRNA transcription and subsequent protein expression in intestinal epithelial cells than did lysates from distal colon. In addition, transrectal administration of cecal contents stimulated Hsp25 and Hsp70 expression in the distal colon. Thus host-microbial interactions resulting in differential Hsp expression may have significant implications for the maintenance of intestinal homeostasis and possibly for development of inflammatory diseases of the bowel.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.