ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
Human aging and CD31+ T-cell number, migration, apoptotic susceptibility, and telomere length.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- CD31Physiological reports · 2026Article
- Article
- Changing landscape of hematopoietic and mesenchymal cells and their interactions during aging and in age-related skeletal pathologies.Mechanisms of ageing and development · 2025Review
- Nonlinear Dynamics of TNFR1 and TNFR2 Expression on Immune Cells: Genetic and Age-Related Aspects of Inflamm-Aging Mechanisms.Biomedicines · 2025Article
- Peripheral blood mononuclear cell number and paracrine function in responses to a 50-km trail race: An exploratory study.Physiological reports · 2025Article
- TB and HIV induced immunosenescence: where do vaccines play a role?Frontiers in aging · 2024Review
- Development and validation of a nomogram to predict mortality risk in patients with ischemic heart disease.Frontiers in cardiovascular medicine · 2023Article
- A subset of gut leukocytes has telomerase-dependent "hyper-long" telomeres and require telomerase for function in zebrafish.Immunity & ageing : I & A · 2022Article
- CD31+ Circulating Angiogenic Cell Number and Subtypes are Reduced in Individuals with Chronic Stroke.Current neurovascular research · 2021Article
- Exercise and Cardiovascular Progenitor Cells.Comprehensive Physiology · 2019Review
- Circulating angiogenic cell response to sprint interval and continuous exercise.European journal of applied physiology · 2019Article
- Unusual mucosal lesion: A case of rectal pseudolipomatosis in a 60-year-old patient.SAGE open medical case reports · 2019Article
- Older men display elevated levels of senescence-associated exercise-responsive CD28Physiological reports · 2018Article
- The association of sarcopenia, telomere length, and mortality: data from the NHANES 1999-2002.European journal of clinical nutrition · 2018Article
- Investigating the extremes of the continuum of paracrine functions in CD34-/CD31+ CACs across diverse populations.American journal of physiology. Heart and circulatory physiology · 2017Article
- Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials.Basic research in cardiology · 2017Article
- Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants.Clinical immunology (Orlando, Fla.) · 2015Article
- Mechanistic insights on immunosenescence and chronic immune activation in HIV-tuberculosis co-infection.World journal of virology · 2015Review
- The pathobiology of vascular dementia.Neuron · 2013Review
- CD31+ T cells, endothelial function and cardiovascular risk.Heart, lung & circulation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
CD31(+) T cells, or so-called "angiogenic T cells," have been shown to demonstrate vasculoprotective and neovasculogenic qualities. The influence of age on CD31(+) T-cell number and function is unclear. We tested the hypothesis that circulating CD31(+) T-cell number and migratory capacity are reduced, apoptotic susceptibility is heightened, and telomere length is shortened with advancing age in adult humans. Thirty-six healthy, sedentary men were studied: 12 young (25 ± 1 yr), 12 middle aged (46 ± 1 yr), and 12 older (64 ± 2 yr). CD31(+) T cells were isolated from peripheral blood samples by magnetic-activated cell sorting. The number of circulating CD31(+) T cells (fluorescence-activated cell sorting analysis) was lower (P < 0.01) in older (24% of CD3(+) cells) compared with middle-aged (38% of CD3(+) cells) and young (40% of CD3(+) cells) men. Migration (Boyden chamber) to both VEGF and stromal cell-derived factor-1α was markedly blunted (P < 0.05) in cells harvested from middle-aged [306.1 ± 45 and 305.6 ± 46 arbitrary units (AU), respectively] and older (231 ± 65 and 235 ± 62 AU, respectively) compared with young (525 ± 60 and 570 ± 62 AU, respectively) men. CD31(+) T cells from middle-aged and older men demonstrated greater apoptotic susceptibility, as staurosporine-stimulated intracellular caspase-3 activation was ∼ 40% higher (P < 0.05) than young. There was a progressive age-related decline in CD31(+) T-cell telomere length (young: 10,706 ± 220 bp; middle-aged: 10,179 ± 251 bp; and older: 9,324 ± 192 bp). Numerical and functional impairments in this unique T-cell subpopulation may contribute to diminished angiogenic potential and greater cardiovascular risk with advancing age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.