ArticleDiabetes2011
Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase.
Article in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Antidiabetic compounds 8a, 8b, 8k, and 9h enhance insulin secretion: activity and mechanism.Endocrine · 2021Article
- The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis.Acta pharmacologica Sinica · 2020Article
- 'Building a perfect body': control of vertebrate organogenesis by PBX-dependent regulatory networks.Genes & development · 2019Review
- Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway.International journal of endocrinology · 2019Article
- MiR-17 family-mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling.Journal of cellular and molecular medicine · 2018Article
- Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin.Nature communications · 2018Article
- Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling.Molecular neurobiology · 2018Article
- Prep1, A Homeodomain Transcription Factor Involved in Glucose and Lipid Metabolism.Frontiers in endocrinology · 2018Review
- A peptide antagonist of Prep1-p160 interaction improves ceramide-induced insulin resistance in skeletal muscle cells.Oncotarget · 2017Article
- Transcriptional control of insulin-sensitive glucose carrier Glut4 expression in adipose tissue cells.Doklady. Biochemistry and biophysics · 2016Article
- Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle.Diabetologia · 2016Article
- Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells.Diabetes · 2014Article
- Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Stage-specific quantitative changes in renal and urinary proteome during the progression and development of streptozotocin-induced diabetic nephropathy in rats.Molecular and cellular biochemistry · 2014Article
- Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance.Reviews in endocrine & metabolic disorders · 2014Review
- Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle.Molecular and cellular biology · 2014Article
- PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.Diabetologia · 2013Article
- Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance.Diabetes · 2012Article
- Article
Corrections and comments
- Retraction · 2019-01-14Duplication of/in Image · Investigation by Company/Institution · Investigation by Journal/Publisher · Unreliable Data · Unreliable Image · Unreliable Results and/or Conclusions ·
- Expression of concern · 2017-11-06Concerns/Issues about Data · Concerns/Issues about Image · Investigation by Company/Institution · Investigation by Journal/Publisher ·
- Expression of concern
- Retracted
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveWe investigated the function of the Prep1 gene in insulin-dependent glucose homeostasis in liver. RESEARCH DESIGN AND
methodsPrep1 action on insulin glucoregulatory function has been analyzed in liver of Prep1-hypomorphic mice (Prep1(i/i)), which express 2-3% of Prep1 mRNA.
resultsBased on euglycemic hyperinsulinemic clamp studies and measurement of glycogen content, livers from Prep1(i/i) mice feature increased sensitivity to insulin. Tyrosine phosphorylation of both insulin receptor (IR) and insulin receptor substrate (IRS)1/2 was significantly enhanced in Prep1(i/i) livers accompanied by a specific downregulation of the SYP and SHP1 tyrosine phosphatases. Prep1 overexpression in HepG2 liver cells upregulated SYP and SHP1 and inhibited insulin-induced IR and IRS1/2 phosphorylation and was accompanied by reduced glycogen content. Consistently, overexpression of the Prep1 partner Pbx1, but not of p160MBP, mimicked Prep1 effects on tyrosine phosphorylations, glycogen content, and on SYP and SHP1 expression. In Prep1 overexpressing cells, antisense silencing of SHP1, but not that of SYP, rescued insulin-dependent IR phosphorylation and glycogen accumulation. Both Prep1 and Pbx1 bind SHP1 promoter at a site located between nucleotides -2,113 and -1,778. This fragment features enhancer activity and induces luciferase function by 7-, 6-, and 30-fold, respectively, in response to Prep1, Pbx1, or both.
conclusionsSHP1, a known silencer of insulin signal, is a transcriptional target of Prep1. In liver, transcriptional activation of SHP1 gene by Prep1 attenuates insulin signal transduction and reduces glucose storage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.