Evidence map›Paper›PMID 20864165›Full record

ArticleBiomaterials2011

An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects.

Yash M Kolambkar, Kenneth M Dupont, Joel D Boerckel, Nathaniel Huebsch, David J Mooney, Dietmar W Hutmacher, Robert E Guldberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed.

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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yash M KolambkarWallace H. Coulter Department of Biomedical Engineering, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr, Atlanta, GA 30332, USA. yash.kolambkar@gmail.com
Kenneth M Dupont
Joel D Boerckel
Nathaniel Huebsch
David J Mooney
Dietmar W Hutmacher
Robert E Guldberg

Funding

Polymeric Matrices with Defined Cell AdhesionR37DE013033 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOONEY, DAVID J · 2004 to 2013
$3.8M
Engineered Delivery of Adult Versus Fetal Stem Cells for Bone RegenerationR01AR056694 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GULDBERG, ROBERT E · 2009 to 2010
$1.3M
Vascularization and Bone RepairR01AR051336 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GULDBERG, ROBERT E · 2004 to 2007
$999k
NIAMS NIH HHS R01 AR051336NIAMS NIH HHS R01 AR056694NIDCR NIH HHS R37 DE013033
6 · The paper itself

Abstract

The treatment of challenging fractures and large osseous defects presents a formidable problem for orthopaedic surgeons. Tissue engineering/regenerative medicine approaches seek to solve this problem by delivering osteogenic signals within scaffolding biomaterials. In this study, we introduce a hybrid growth factor delivery system that consists of an electrospun nanofiber mesh tube for guiding bone regeneration combined with peptide-modified alginate hydrogel injected inside the tube for sustained growth factor release. We tested the ability of this system to deliver recombinant bone morphogenetic protein-2 (rhBMP-2) for the repair of critically-sized segmental bone defects in a rat model. Longitudinal μ-CT analysis and torsional testing provided quantitative assessment of bone regeneration. Our results indicate that the hybrid delivery system resulted in consistent bony bridging of the challenging bone defects. However, in the absence of rhBMP-2, the use of nanofiber mesh tube and alginate did not result in substantial bone formation. Perforations in the nanofiber mesh accelerated the rhBMP-2 mediated bone repair, and resulted in functional restoration of the regenerated bone. μ-CT based angiography indicated that perforations did not significantly affect the revascularization of defects, suggesting that some other interaction with the tissue surrounding the defect such as improved infiltration of osteoprogenitor cells contributed to the observed differences in repair. Overall, our results indicate that the hybrid alginate/nanofiber mesh system is a promising growth factor delivery strategy for the repair of challenging bone injuries.

Indexed as

AlginatesAngiographyAnimalsBiomechanical PhenomenaBone Morphogenetic Protein 2Bone Morphogenetic ProteinsBone RegenerationDrug Delivery SystemsFemurGlucuronic AcidHexuronic AcidsHumansImplants, ExperimentalKineticsNanofibersRatsAlginatesBone Morphogenetic Protein 2Bone Morphogenetic ProteinsGlucuronic AcidHexuronic Acidsrecombinant human bone morphogenetic protein-2Recombinant ProteinsTransforming Growth Factor beta

Identifiers

PMID20864165
PMCPMC3013370

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.